2015
Tapentadol extended release in the management of peripheral diabetic neuropathic pain
Vadivelu N, Kai A, Maslin B, Kodumudi G, Legler A, Berger JM. Tapentadol extended release in the management of peripheral diabetic neuropathic pain. Therapeutics And Clinical Risk Management 2015, Volume 11: 95-105. PMID: 25609974, PMCID: PMC4298300, DOI: 10.2147/tcrm.s32193.Peer-Reviewed Original ResearchPainful diabetic neuropathyDiabetic neuropathyOpioid-based therapyCancer-related painDiabetic neuropathic painChronic pain conditionsGastrointestinal side effectsNorepinephrine reuptake inhibitorsΜ-opioid agonistMechanism of actionNeuropathic painPain conditionsReuptake inhibitorsBack painArthritic painClinical efficacyEffective medicationsClinical studiesSide effectsPainTapentadolNeuropathyOne-thirdMedicationsDiabetes
2014
Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonist
2011
Tapentadol extended-release for treatment of chronic pain: a review
Vadivelu N, Timchenko A, Huang Y, Sinatra R. Tapentadol extended-release for treatment of chronic pain: a review. Journal Of Pain Research 2011, Volume 4: 211-218. PMID: 21887118, PMCID: PMC3160834, DOI: 10.2147/jpr.s14842.Peer-Reviewed Original ResearchLow back painNeuropathic painBack painCancer-related neuropathic painSevere chronic osteoarthritis painCentral nervous system effectsBetter gastrointestinal tolerabilityCancer-related painChronic neuropathic painDiabetic peripheral neuropathySevere acute painChronic osteoarthritis painMajor adverse eventsChronic pain conditionsNervous system effectsNorepinephrine reuptake inhibitionAnalgesic effectivenessEffective analgesiaGastrointestinal intoleranceGastrointestinal tolerabilityOsteoarthritis painAcute painAdverse eventsChronic osteoarthritisPain conditions