2013
Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter
Arshad N, Visweswariah SS. Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter. WIREs Mechanisms Of Disease 2013, 5: 409-424. PMID: 23610087, DOI: 10.1002/wsbm.1223.Peer-Reviewed Original ResearchConceptsIntestinal epithelial cell homeostasisEpithelial cell homeostasisCyclic AMPCyclic nucleotidesWeb of interactionsNucleotidyl cyclasesSymbiotic microbiotaTranscription factorsProtein kinaseIntestinal epitheliumDownstream effectorsCell homeostasisDiverse processesIntestinal epithelial cellsSecond messengerCyclic GMPIon channelsNutrient absorptionIntrinsic cuesCell proliferationNeoplastic growthEpithelial cellsPathwayNucleotidesKey processes
2012
The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis
Arshad N, Visweswariah SS. The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis. FEBS Letters 2012, 586: 2835-2840. PMID: 22819815, DOI: 10.1016/j.febslet.2012.07.028.Peer-Reviewed Original ResearchConceptsGuanylyl cyclase CCyclase CGut immune systemIntestinal epithelial cellsColon cell proliferationTravelers' diarrheaIntestinal homeostasisHeat-stable enterotoxinImmune systemActivation of GCIon secretionEpithelial cellsCell proliferationCausative agentDiarrheaIntracellular levelsFirst descriptionReceptorsRecent findingsFuture studiesHuman diseasesEnigmatic roleNew findingsDiseaseFindingsFamilial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation
Fiskerstrand T, Arshad N, Haukanes BI, Tronstad RR, Pham KD, Johansson S, Håvik B, Tønder SL, Levy SE, Brackman D, Boman H, Biswas KH, Apold J, Hovdenak N, Visweswariah SS, Knappskog PM. Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation. New England Journal Of Medicine 2012, 366: 1586-1595. PMID: 22436048, DOI: 10.1056/nejmoa1110132.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane regulatorEntire candidate regionCandidate regionsExons of genesHEK293T cellsAffected family membersCyclic guanosine monophosphateSingle nucleotide polymorphismsBacterial heat-stable enterotoxinsFamily membersMutant receptorsChromosome 12GC-C signalingMutant GcRecessive mutationsLinkage analysisTransmembrane regulatorFunctional studiesMissense mutationsGenetic variantsHeterozygous missense mutationMutationsExome sequencingGUCY2C mutationGenes