Comprehensive Analysis of Metabolic Isozyme Targets in Cancer
Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O'Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L. Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. Cancer Research 2022, 82: 1698-1711. PMID: 35247885, PMCID: PMC10883296, DOI: 10.1158/0008-5472.can-21-3983.Peer-Reviewed Original ResearchConceptsPotential therapeutic targetAcetyl-CoA carboxylase 1Therapeutic targetCancer typesCell linesBreast cancer viabilityPatient-derived xenograftsNovel metabolic targetsCorresponding cell linesExpression patternsDrug treatmentMatching normal tissuesRelated commentaryTumor growthMalignant transformationSmall molecule inhibitionCancer viabilityCancer Cell Line EncyclopediaNormal tissuesMetabolic vulnerabilitiesCarboxylase 1Anticancer therapyCellular changesCell proliferationMetabolic reprogrammingAnalysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds
Shan N, Minden A, Furmanski P, Bak M, Cai L, Wernyj R, Sargsyan D, Cheng D, Wu R, Kuo H, Li S, Fang M, Maehr H, Kong A, Suh N. Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds. Cancer Prevention Research 2020, 13: 673-686. PMID: 32467291, PMCID: PMC7415686, DOI: 10.1158/1940-6207.capr-19-0566.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCell Line, TumorCell ProliferationDatasets as TopicDisease ProgressionDNA MethylationDown-RegulationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplastic Stem CellsRNA-SeqSignal TransductionUp-RegulationVitamin DConceptsCancer stem-like cellsStem-like cellsInvasive ductal carcinomaVitamin D compoundsNext-generation RNA sequencingCancer stem cell-like populationsGlobal transcriptomic analysisStem cell-like populationIngenuity Pathway AnalysisDuctal carcinomaCell-like populationD compoundsTranscriptomic analysisVitamin DGene methylation statusRNA sequencingEpithelial-mesenchymal transitionGlobal profilingPathway genesBreast cancer stem-like cellsCanonical pathwaysNegative regulatorUpstream regulatorPathway analysisNew breast cancer diagnosesVitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer
Shan N, Wahler J, Lee H, Bak M, Gupta S, Maehr H, Suh N. Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer. The Journal Of Steroid Biochemistry And Molecular Biology 2016, 173: 122-129. PMID: 27923595, PMCID: PMC5459680, DOI: 10.1016/j.jsbmb.2016.12.001.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerVitamin D compoundsCancer stem-like cellsNegative breast cancerBreast cancerStem-like cellsVitamin DCancer stem cellsD compoundsGemini vitamin D analog BXL0124Early breast cancer preventionBreast cancer stem-like cellsBreast cancer stem cell maintenanceBasal-like breast cancerMammosphere cultureBreast cancer preventionCancer cellsCancer stem cell markersPotential preventive agentBreast cancer subtypesBreast cancer cell linesTriple-negative breast cancer cell linesSmooth muscle actinBreast cancer cellsStem-like properties