Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds
Shan N, Minden A, Furmanski P, Bak M, Cai L, Wernyj R, Sargsyan D, Cheng D, Wu R, Kuo H, Li S, Fang M, Maehr H, Kong A, Suh N. Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds. Cancer Prevention Research 2020, 13: 673-686. PMID: 32467291, PMCID: PMC7415686, DOI: 10.1158/1940-6207.capr-19-0566.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCell Line, TumorCell ProliferationDatasets as TopicDisease ProgressionDNA MethylationDown-RegulationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplastic Stem CellsRNA-SeqSignal TransductionUp-RegulationVitamin DConceptsCancer stem-like cellsStem-like cellsInvasive ductal carcinomaVitamin D compoundsNext-generation RNA sequencingCancer stem cell-like populationsGlobal transcriptomic analysisStem cell-like populationIngenuity Pathway AnalysisDuctal carcinomaCell-like populationD compoundsTranscriptomic analysisVitamin DGene methylation statusRNA sequencingEpithelial-mesenchymal transitionGlobal profilingPathway genesBreast cancer stem-like cellsCanonical pathwaysNegative regulatorUpstream regulatorPathway analysisNew breast cancer diagnosesBreast cancer stem cells: A review of their characteristics and the agents that affect them
Shan N, Shin Y, Yang G, Furmanski P, Suh N. Breast cancer stem cells: A review of their characteristics and the agents that affect them. Molecular Carcinogenesis 2021, 60: 73-100. PMID: 33428807, PMCID: PMC7855917, DOI: 10.1002/mc.23277.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBreast cancer stem cellsCancer stem cellsBreast cancerCell surface markersCombination therapyTherapeutic effectNew tumorsEffective treatmentXenografted miceCancer developmentSurface markersSerial transplantationCancerPotential agentFurther studiesTranscription factorsTumorsStem cellsBiological effects