KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells
Cordover E, Wei J, Patel C, Shan N, Gionco J, Sargsyan D, Wu R, Cai L, Kong A, Jacinto E, Minden A. KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells. Chemical Research In Toxicology 2019, 33: 482-491. PMID: 31876149, PMCID: PMC9316853, DOI: 10.1021/acs.chemrestox.9b00376.Peer-Reviewed Original ResearchConceptsCell growthSerine/threonine kinase mTORNicotinamide phosphoribosyltransferaseBreast cancer cellsTNBC cellsRegulation of RictorPak4 protein kinaseCancer cellsInhibition of PAK4Triple-negative breast cancerTriple-negative breast cancer cellsMTORC2 signalingKinase mTORProtein kinaseRNA sequencingTNBC cell growthNegative breast cancer cellsCell metabolismRictorPAK4Overexpressing cellsSpecific inhibitorDruggable targetsMTOR pathwayInhibits growth