2024
The diagnostic value of the central vein sign in radiologically isolated syndrome
Landes‐Chateau C, Levraut M, Okuda D, Themelin A, Cohen M, Kantarci O, Siva A, Pelletier D, Mondot L, Lebrun‐Frenay C, Lebrun‐Frenay C, Kantarci O, Siva A, Pelletier D, Azevedo C, Makhani N, Okuda D. The diagnostic value of the central vein sign in radiologically isolated syndrome. Annals Of Clinical And Translational Neurology 2024, 11: 662-672. PMID: 38186317, PMCID: PMC10963291, DOI: 10.1002/acn3.51986.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersDemyelinating DiseasesHumansMagnetic Resonance ImagingMultiple SclerosisSensitivity and SpecificityConceptsRadiologically isolated syndromeCentral vein signCVS+ lesionsNon-MSMultiple sclerosisControl group of sex-RIS diagnosisAge-matched subjectsDetectable preclinical phaseProportion of lesionsWhite matter lesionsGroup of sex-Effective imaging biomarkerMagnetic resonance imagingDiagnostic performanceDiagnostic accuracyDiagnostic valueLesion criteriaImaging biomarkersLesionsResonance imagingLesion-specificAbsolute numberControl groupROC comparisons
2023
The radiologically isolated syndrome: revised diagnostic criteria
Lebrun-Frénay C, Okuda D, Siva A, Landes-Chateau C, Azevedo C, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud D, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci O. The radiologically isolated syndrome: revised diagnostic criteria. Brain 2023, 146: 3431-3443. PMID: 36864688, PMCID: PMC11004931, DOI: 10.1093/brain/awad073.Peer-Reviewed Original ResearchMeSH KeywordsAdultDemyelinating DiseasesDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisRisk FactorsConceptsRadiologically isolated syndromeClinical eventsGroup 1Risk factorsDIS criteriaPresence of spinal cord lesionsClinical follow-up timeCSF-restricted oligoclonal bandsMultivariate Cox regression modelDiagnostic criteriaFocal T2 hyperintensitiesGadolinium-enhancing lesionsMultiple sclerosisNegative predictive valueFollow-up scansFollow-up timeArea under the curveClass I evidenceSpinal cord lesionsCox regression modelsRisk of developmentWhite matter lesionsProspective databaseSymptomatic MST2 lesions
2021
The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients – Commentary
Makhani N. The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients – Commentary. Multiple Sclerosis Journal 2021, 27: 1827-1828. PMID: 34494919, PMCID: PMC8740898, DOI: 10.1177/13524585211044951.Peer-Reviewed Original Research
2020
Radiologically Isolated Syndrome: 10‐Year Risk Estimate of a Clinical Event
Lebrun‐Frenay C, Kantarci O, Siva A, Sormani M, Pelletier D, Okuda D, Azevedo C, Amato M, Bensa C, Berger E, Brochet B, Ciron J, Cohen M, Inglese M, Keegan B, Labauge P, Laplaud D, Le Page E, Louapre C, Makhani N, Mathey G, Mondot L, Montalban X, Pelletier J, Seze J, deStefano N, Thouvenot E, Tintore M, Tutuncuoglu M, Uygunoglu U, Vermersch P, Weinshenker B, Zeydan B. Radiologically Isolated Syndrome: 10‐Year Risk Estimate of a Clinical Event. Annals Of Neurology 2020, 88: 407-417. PMID: 32500558, DOI: 10.1002/ana.25799.Peer-Reviewed Original ResearchConceptsFirst clinical eventSubsequent clinical eventsGadolinium-enhancing lesionsSpinal cord lesionsClinical eventsRIS subjectsCord lesionsIndependent predictorsMultivariate Cox regression modelMagnetic resonance imaging (MRI) characteristicsBaseline independent predictorsWorldwide cohort studiesPositive cerebrospinal fluidCox regression modelAnn NeurolIsolated SyndromeRIS diagnosisCohort studySymptom onsetMale sexMultiple sclerosisOligoclonal bandsInfratentorial lesionsMean ageClinical management
2015
Radiologically Isolated Syndrome in a Pediatric Patient
George IC, DeStefano K, Makhani N. Radiologically Isolated Syndrome in a Pediatric Patient. Pediatric Neurology 2015, 56: 86-87. PMID: 26724214, DOI: 10.1016/j.pediatrneurol.2015.10.013.Peer-Reviewed Original ResearchViral exposures and MS outcome in a prospective cohort of children with acquired demyelination
Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O’Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A, Network O. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Multiple Sclerosis Journal 2015, 22: 385-388. PMID: 26199356, DOI: 10.1177/1352458515595876.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralChickenpoxChildCohort StudiesCytomegalovirus InfectionsDemyelinating DiseasesEnzyme-Linked Immunosorbent AssayEpstein-Barr Virus InfectionsFemaleHerpes SimplexHumansImmunoglobulin GMaleMultiple SclerosisProportional Hazards ModelsProspective StudiesSeroepidemiologic StudiesConceptsCMV infectionEpstein-Barr virus infectionRemote EBV infectionSubsequent MS diagnosisImportant prognostic informationMultiple sclerosis riskVaricella-zoster virusHerpes simplex virusCMV seroprevalenceDemyelinating syndromesMonophasic ADSEBV infectionCytomegalovirus infectionProspective cohortMS diagnosisViral exposurePrognostic informationMS outcomesVirus infectionHigh riskSimplex virusMS developmentInfectionProtective factorsChildren