Elevated mutant frequencies and increased C : G→T : A transitions in Mlh1−/− versus Pms2−/− murine small intestinal epithelial cells
Baross-Francis A, Makhani N, Liskay R, Jirik F. Elevated mutant frequencies and increased C : G→T : A transitions in Mlh1−/− versus Pms2−/− murine small intestinal epithelial cells. Oncogene 2001, 20: 619-625. PMID: 11313994, DOI: 10.1038/sj.onc.1204138.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAnimalsBase Pair MismatchCarrier ProteinsCrosses, GeneticDNA Mutational AnalysisDNA Repair EnzymesDNA-Binding ProteinsEpithelial CellsFemaleIntestinal NeoplasmsIntestine, SmallMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicMismatch Repair Endonuclease PMS2MutL Protein Homolog 1Neoplasm ProteinsNuclear ProteinsPoint MutationConceptsMurine small intestinal epithelial cellsGenomic instabilitySmall intestinal epithelial cellsIntestinal epithelial cellsEpithelial cellsMutant frequencyGene targetingReporter systemT mispairsΛ phageDNA mismatch repair genesRepair genesMismatch repair genesPhenotypic dichotomyMutational spectrumMutation spectrumWild-type littermatesMutationsIntestinal adenomasElevated mutant frequenciesImportant roleCellsSmall intestinal adenomasGenesHeterodimers