2020
Identification and characterization of functional long noncoding RNAs in cancer
Olivero CE, Dimitrova N. Identification and characterization of functional long noncoding RNAs in cancer. The FASEB Journal 2020, 34: 15630-15646. PMID: 33058262, PMCID: PMC7756267, DOI: 10.1096/fj.202001951r.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinogenesisEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansNeoplasmsRNA, Long Noncoding
2014
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint
Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint. Molecular Cell 2014, 54: 777-790. PMID: 24857549, PMCID: PMC4103188, DOI: 10.1016/j.molcel.2014.04.025.Peer-Reviewed Original ResearchConceptsG1/S checkpointGene expressionS checkpointPolycomb target genesGlobal gene expressionP53 transcriptional networkTarget gene expressionTumor suppressor pathwayConditional knockout mouse modelP53 tumor suppressor pathwayChromatin stateTranscriptional networksKnockout mouse modelNeighboring genesMRNA translationProtein stabilityTarget genesP21 transcriptionSuppressor pathwayAdditional phenotypesGenesP21 levelsLincRNA-p21P21 expressionCoactivator