2024
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
Ferrer J, Dimitrova N. Transcription regulation by long non-coding RNAs: mechanisms and disease relevance. Nature Reviews Molecular Cell Biology 2024, 25: 396-415. PMID: 38242953, PMCID: PMC11045326, DOI: 10.1038/s41580-023-00694-9.Peer-Reviewed Original ResearchCis-regulatory functionLong non-coding RNAsGene transcriptionNon-coding RNAsTranscription factorsControl of gene transcriptionProtein-coding transcriptsActivation of gene transcriptionDosage-sensitive genesEncode transcription factorsX-chromosome inactivationTranscription unitTranscription elongationGenetic experimentsTranscriptional regulationTranscript stabilityCharacterized lncRNATranscriptionHuman diseasesFindings of lncRNAsImprinted lncRNAsLncRNA involvementLincRNA-p21Severe phenotypeLncRNAs
2014
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint
Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint. Molecular Cell 2014, 54: 777-790. PMID: 24857549, PMCID: PMC4103188, DOI: 10.1016/j.molcel.2014.04.025.Peer-Reviewed Original ResearchConceptsG1/S checkpointGene expressionS checkpointPolycomb target genesGlobal gene expressionP53 transcriptional networkTarget gene expressionTumor suppressor pathwayConditional knockout mouse modelP53 tumor suppressor pathwayChromatin stateTranscriptional networksKnockout mouse modelNeighboring genesMRNA translationProtein stabilityTarget genesP21 transcriptionSuppressor pathwayAdditional phenotypesGenesP21 levelsLincRNA-p21P21 expressionCoactivator