Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men With Localized Prostate Cancer
Housri N, Ning H, Ondos J, Choyke P, Camphausen K, Citrin D, Arora B, Shankavaram U, Kaushal A. Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men With Localized Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2010, 80: 614-620. PMID: 20932672, PMCID: PMC3580994, DOI: 10.1016/j.ijrobp.2010.06.050.Peer-Reviewed Original ResearchConceptsSimultaneous integrated boostIntraprostatic lesionIntegrated boostPrescribed doseDose constraintsCurrent phase I trialRadiation Therapy Oncology Group (RTOG) protocolBladder dose constraintsHigh-dose cohortPhase I trialLocalized prostate cancerRadiation dose escalationIntensity-modulated radiotherapy plansHigh-dose radiationDominant intraprostatic lesionCritical normal tissuesDose cohortsDose escalationI trialProstate cancerIndividual patientsCT scanMRI scansCancer lesionsSmall cohort