2013
Characterization of CFTR High Expresser cells in the intestine
Jakab RL, Collaco AM, Ameen NA. Characterization of CFTR High Expresser cells in the intestine. AJP Gastrointestinal And Liver Physiology 2013, 305: g453-g465. PMID: 23868408, PMCID: PMC3761243, DOI: 10.1152/ajpgi.00094.2013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAlkaline PhosphataseAnimalsCyclic AMPCystic Fibrosis Transmembrane Conductance RegulatorIntestinal MucosaIntestine, SmallMaleMicrovilliProtein TransportQa-SNARE ProteinsRatsRats, Sprague-DawleySodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersSodium-Potassium-Exchanging ATPaseSolute Carrier Family 12, Member 2ConceptsCHE cellsNeighboring enterocytesVacuolar ATPase proton pumpCystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channelDouble-label immunofluorescence microscopyEightfold higher levelsBrush border membraneRegulatory factors NHERF1Crypt-villus axisCFTR abundanceSyntaxin 3Myosin-1aApical domain
2000
Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract
Ameen N, Alexis J, Salas P. Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract. Histochemistry And Cell Biology 2000, 114: 69-75. PMID: 10959824, DOI: 10.1007/s004180000164.Peer-Reviewed Original ResearchConceptsMouse intestinal tractCystic fibrosisIntestinal tractCystic fibrosis transmembrane conductance regulatorSmall intestinal obstructionSevere gastrointestinal diseasePathophysiology of CFMouse model systemFibrosis transmembrane conductance regulatorVillus distributionTransmembrane conductance regulatorIntestinal obstructionDifferent phenotypic expressionsCF intestineGastrointestinal diseasesBicarbonate secretionTransgenic miceHuman CF diseaseSmall intestineDisease expressionImmunoblot techniqueLethal obstructionMouse intestineMiceConductance regulator