2013
Characterization of CFTR High Expresser cells in the intestine
Jakab RL, Collaco AM, Ameen NA. Characterization of CFTR High Expresser cells in the intestine. AJP Gastrointestinal And Liver Physiology 2013, 305: g453-g465. PMID: 23868408, PMCID: PMC3761243, DOI: 10.1152/ajpgi.00094.2013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAlkaline PhosphataseAnimalsCyclic AMPCystic Fibrosis Transmembrane Conductance RegulatorIntestinal MucosaIntestine, SmallMaleMicrovilliProtein TransportQa-SNARE ProteinsRatsRats, Sprague-DawleySodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersSodium-Potassium-Exchanging ATPaseSolute Carrier Family 12, Member 2ConceptsCHE cellsNeighboring enterocytesVacuolar ATPase proton pumpCystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channelDouble-label immunofluorescence microscopyEightfold higher levelsBrush border membraneRegulatory factors NHERF1Crypt-villus axisCFTR abundanceSyntaxin 3Myosin-1aApical domain
2008
S1771 Regulated Exocytosis and Fusion of Vesicle Associated CFTR to the Apical Plasma Membrane of the Intestine Is Mediated By the Snare Protein Syntaxin-3
Ameen N, Collaco A. S1771 Regulated Exocytosis and Fusion of Vesicle Associated CFTR to the Apical Plasma Membrane of the Intestine Is Mediated By the Snare Protein Syntaxin-3. Gastroenterology 2008, 134: a-266. DOI: 10.1016/s0016-5085(08)61239-1.Peer-Reviewed Original Research
2001
Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia
Ameen N, Figueroa Y, Salas P. Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia. Journal Of Cell Science 2001, 114: 563-575. PMID: 11171325, DOI: 10.1242/jcs.114.3.563.Peer-Reviewed Original ResearchConceptsIntermediate filamentsPolarized epithelial cellsApical membrane proteinsEpithelial cellsSyntaxin 3Apical domainFemale sterilityMembrane proteinsApical markerNovel functionGamma-tubulinNovel roleApical poleSimple epitheliaCell typesColorectal hyperplasiaCK intermediate filamentsNull micePhenotypeBasolateral levelsNecrotic cellsMembrane phenotypeCellsFilamentsCytoplasm of enterocytes