2015
Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI
Hegan PS, Kravtsov DV, Caputo C, Egan ME, Ameen NA, Mooseker MS. Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI. Cytoskeleton 2015, 72: 455-476. PMID: 26286357, PMCID: PMC4715533, DOI: 10.1002/cm.21238.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisCell MembraneCell NucleusColitisCrosses, GeneticCystic Fibrosis Transmembrane Conductance RegulatorCytoskeletonDisease ProgressionDuodenumEndosomesEpitheliumGenotypeIn Situ Nick-End LabelingIntestinal MucosaIntestinesMaleMiceMice, KnockoutMicroscopy, Electron, TransmissionMicroscopy, FluorescenceMicrovilliMutationMyosin Heavy ChainsMyosin Type IPhosphatesConceptsActin coreMyosin VIIntestinal epithelial cellsMutant miceMyosin IAMembrane traffickingActin cytoskeletonBB membraneMembrane proteins
2013
Role of Myosin1a in regulated exocytosis of CFTR in villus enterocytes
Hoekstra N, Kravtsov D, Mooseker M, Ameen N. Role of Myosin1a in regulated exocytosis of CFTR in villus enterocytes. The FASEB Journal 2013, 27: 913.11-913.11. DOI: 10.1096/fasebj.27.1_supplement.913.11.Peer-Reviewed Original ResearchSurface biotinylationRegulated exocytosisCFTR trafficSurface CFTRSubapical endosomesBrush border membraneMembrane traffickingCFTR deliveryKD cellsKnockdown cellsCFTR channelsCFTR distributionVillus enterocytesMolecular mechanismsEnterocyte brush border membraneCFTRBiotinylationConfocal microscopyEndosomesIntestinal brush border membraneMouse intestineExocytosisCGMP agonistMyo1aBorder membrane