Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells
Hoque K, Hayashi M, Sheikh I, Banerjee A, Verma S, Leblanc N, Zeiss C, Ameen N, Chakraborty S. Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells. The FASEB Journal 2022, 36: 10.1096/fasebj.2022.36.s1.0r556. PMCID: PMC9348250, DOI: 10.1096/fasebj.2022.36.s1.0r556.Peer-Reviewed Original ResearchEnterochromaffin cell hyperplasiaCalu-3 cellsSARS-CoV2 infectionCl(-) secretionIntestinal epitheliumCell hyperplasiaColonic tissueCalcium-activated Cl- currentsCOVID-19-associated diarrheaCalcium-activated chloride currentsHuman colorectal cancer tissuesANO1 protein expressionCOVID-19 therapyIntestinal Cl(-) secretionColorectal cancer tissuesUssing chamber experimentsANO1 currentsSeverity of symptomsCOVID-19Human terminal ileumHuman intestinal epitheliumIntestinal epithelial cellsWhole-cell currentsHuman colonic tissueCaco-2 cells