2017
Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders
Korem N, Lange R, Hillard C, Akirav I. Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. Neuroscience 2017, 357: 285-294. PMID: 28624572, DOI: 10.1016/j.neuroscience.2017.06.015.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderWnt/β-catenin pathwayNucleus accumbensΒ-catenin pathwayΒ-catenin levelsΒ-cateninCannabinoid CB1/2 receptor agonistCB1/2 receptor agonistEndocannabinoid N-arachidonylethanolamineStress-related disordersΒ-catenin expressionReceptor agonistEndocannabinoid systemTherapeutic effectN-arachidonylethanolamineDepressive symptomsDevelopment of psychopathologyImpaired extinctionRatsStress disorderFear memoryTrauma memoriesRapid recoveryReminders modelAccumbens
2016
Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood
Alteba S, Korem N, Akirav I. Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood. Learning & Memory 2016, 23: 349-358. PMID: 27317195, PMCID: PMC4918780, DOI: 10.1101/lm.041608.116.Peer-Reviewed Original ResearchConceptsEarly life stressLate adolescenceRecognition taskLife stressCannabinoid CB1/2 receptor agonistNovel object recognition taskEffects of ELSSocial recognition taskShort-term memoryCB1/2 receptor agonistObject recognition taskAnxiety-related disordersStress-induced impairmentRecognition memoryFear circuitImpaired performanceNeurocognitive performanceTreatment of stressCognitive deficitsNeurocognitive functionAnxiety levelsCB1 receptorsEarly stressPFC GRSpatial location
2014
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Korem N, Akirav I. Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing. Neuropsychopharmacology 2014, 39: 2709-2722. PMID: 24897957, PMCID: PMC4200492, DOI: 10.1038/npp.2014.132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoxazinesBrainCannabinoid Receptor AgonistsCannabinoidsCuesDisease Models, AnimalElectroshockEmotionsExtinction, PsychologicalLong-Term PotentiationMaleMorpholinesNaphthalenesNeuronal PlasticityRats, Sprague-DawleyReceptors, CannabinoidReceptors, GlucocorticoidReflex, StartleSpace PerceptionStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderSituational remindersEmotional processingPrefrontal cortexTrauma exposureTraumatic eventsBasolateral amygdalaPTSD-like symptomsTrajectory of PTSDCB1/2 receptor agonistCB1 receptorsGlucocorticoid receptorImpaired extinctionSingle footshockStress disorderBrain areasFootshockCB1R expressionImpaired plasticityReceptor agonistDay 1Day 3ProcessingCA1Altered expression