2018
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity
Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, Hillard C, Akirav I. Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. Neuropsychopharmacology 2018, 43: 2017-2027. PMID: 29977073, PMCID: PMC6098035, DOI: 10.1038/s41386-018-0135-4.Peer-Reviewed Original ResearchConceptsLong-term potentiationPosttraumatic stress disorderBasolateral amygdalaSituational remindersEmotional memoryFatty acid amide hydrolase inhibitor URB597Fear responsesCB1 receptor antagonist AM251Effects of URB597Receptor antagonist AM251Role of endocannabinoidsDevelopment of PTSDHippocampal CA1 areaTrauma-related cuesEndogenous cannabinoid levelsSevere footshockAntagonist AM251Endocannabinoid contentAEA levelsCA1 areaEffects of exposureRisk factorsFAAH activityTreatment responseFAAH inhibition
2017
Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders
Korem N, Lange R, Hillard C, Akirav I. Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. Neuroscience 2017, 357: 285-294. PMID: 28624572, DOI: 10.1016/j.neuroscience.2017.06.015.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderWnt/β-catenin pathwayNucleus accumbensΒ-catenin pathwayΒ-catenin levelsΒ-cateninCannabinoid CB1/2 receptor agonistCB1/2 receptor agonistEndocannabinoid N-arachidonylethanolamineStress-related disordersΒ-catenin expressionReceptor agonistEndocannabinoid systemTherapeutic effectN-arachidonylethanolamineDepressive symptomsDevelopment of psychopathologyImpaired extinctionRatsStress disorderFear memoryTrauma memoriesRapid recoveryReminders modelAccumbens
2014
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Korem N, Akirav I. Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing. Neuropsychopharmacology 2014, 39: 2709-2722. PMID: 24897957, PMCID: PMC4200492, DOI: 10.1038/npp.2014.132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoxazinesBrainCannabinoid Receptor AgonistsCannabinoidsCuesDisease Models, AnimalElectroshockEmotionsExtinction, PsychologicalLong-Term PotentiationMaleMorpholinesNaphthalenesNeuronal PlasticityRats, Sprague-DawleyReceptors, CannabinoidReceptors, GlucocorticoidReflex, StartleSpace PerceptionStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderSituational remindersEmotional processingPrefrontal cortexTrauma exposureTraumatic eventsBasolateral amygdalaPTSD-like symptomsTrajectory of PTSDCB1/2 receptor agonistCB1 receptorsGlucocorticoid receptorImpaired extinctionSingle footshockStress disorderBrain areasFootshockCB1R expressionImpaired plasticityReceptor agonistDay 1Day 3ProcessingCA1Altered expression