2020
N6-methyladenine in DNA antagonizes SATB1 in early development
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Min W, Jiang Z, Wang Y, Li H, Xiao AZ. N6-methyladenine in DNA antagonizes SATB1 in early development. Nature 2020, 583: 625-630. PMID: 32669713, PMCID: PMC8596487, DOI: 10.1038/s41586-020-2500-9.Peer-Reviewed Original ResearchConceptsN6-mAN6-methyladenineMouse trophoblast stem cellsLarge chromatin domainsCell fate transitionsLarge-scale chromatinUnexpected molecular mechanismTrophoblast stem cellsEarly embryonic developmentDNA secondary structuresEarly developmentFate transitionsMammalian genomesChromatin domainsEpigenetic landscapeGene regulationChromatin organizerEmbryonic developmentDNA modificationsBiological roleMolecular mechanismsSATB1 functionsMolecular pathwaysCell culture modelSecondary structure
2017
The Systemic Effects of Endometriosis
Alderman MH, Yoder N, Taylor HS. The Systemic Effects of Endometriosis. Seminars In Reproductive Medicine 2017, 35: 263-270. PMID: 28658710, DOI: 10.1055/s-0037-1603582.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic effectsTreatment of patientsMultiple organ systemsMore effective treatmentsPelvic painEndometrial glandsAutoimmune diseasesBroader systemic effectsCardiovascular diseaseEffective treatmentEndometriosisBody weightPsychiatric conditionsOrgan systemsEctopic locationsStem cell migrationDiseaseComorbiditiesCell migrationTreatmentHypothesized mechanismsDysmenorrheaPainPatientsPathophysiology