2021
Molecular mechanisms of estrogen action in female genital tract development
Alderman MH, Taylor HS. Molecular mechanisms of estrogen action in female genital tract development. Differentiation 2021, 118: 34-40. PMID: 33707128, PMCID: PMC8073215, DOI: 10.1016/j.diff.2021.01.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGene expressionSelective estrogen receptor modulatorsFemale genital tract developmentAberrant CpG methylationGenital tract developmentHistone modificationsEpigenetic regulationOrgan developmentCpG methylationTranscriptional pathwaysSpecific fetalEpigenetic modulationMolecular mechanismsFemale reproductive tractLate organogenesisHormonal regulationOrganogenesisEstrogen receptor modulatorsTract developmentReproductive tractIndependent fashionRegulationDisease statesEstrogen actionReceptor modulators
2016
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen EM, Alderman MH, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure. The FASEB Journal 2016, 30: 3194-3201. PMID: 27312807, PMCID: PMC5001514, DOI: 10.1096/fj.201500089r.Peer-Reviewed Original ResearchConceptsEstrogen responseSubsequent gene expressionGene expressionXenoestrogen exposureBPA exposureEpigenetic programmingUtero BPA exposurePrenatal BPA exposureRisk of estrogenMajority of genesNormal developmental programmingFemale reproductive disordersCpG methylation patternsCpG methylation profilesEstrogen-responsive gene expressionUterine DNAEstrogen-responsive genesEndometrial hyperplasiaUtero exposurePregnant miceEtiological factorsBreast cancerEstrogen receptorMethylation patternsRelevant dose