Featured Publications
WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation
Kulkarni SS, Griffin JN, Date PP, Liem KF, Khokha MK. WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation. Developmental Cell 2018, 46: 595-610.e3. PMID: 30205038, PMCID: PMC6177229, DOI: 10.1016/j.devcel.2018.08.009.Peer-Reviewed Original ResearchConceptsMulticiliated cellsF-actinBasal bodiesHundreds of ciliaApical actin networkApical F-actinApical actinChromatin modificationsChromatin modifiersTissue morphogenesisActin cytoskeletonActin architectureActin networkWDR5Intracellular organellesG-actinCell surfaceCell formationCellsCytoskeletonMorphogenesisOrganellesRegulatorActinBinds
2024
The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure
Nama K, Su B, Marquez J, Khokha M, Habas R. The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure. Developmental Dynamics 2024 PMID: 38877839, DOI: 10.1002/dvdy.720.Peer-Reviewed Original ResearchWnt signaling pathwayActin cytoskeletonSub-cellular localization studiesFormin homology proteinsSignaling pathwayNon-canonical Wnt pathwayCellular actin cytoskeletonActin filament formationActin cytoskeleton modulationMammalian cultured cellsCo-immunoprecipitation assaysNeural tube morphogenesisNon-canonical signalingStem cell homeostasisNon-canonical pathwayNeural tube closure defectsNeural tube closureVertebrate gastrulationCytoskeleton modulationCell polarityFate determinationCellular processesTube morphogenesisCo-immunoprecipitationVertebrate development