2015
Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells
Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Arcuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells. The Journal Of Pathology 2015, 237: 423-434. PMID: 26175191, DOI: 10.1002/path.4589.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionPreterm birthDecidual cellsPR expressionIL-1βDC culturesReceptor expressionPR levelsIL-1β suppressionLower PR levelsFunctional progesterone withdrawalCOX-2 expressionRelease of cytokinesIL-1β treatmentDecidual prostaglandin productionP38 MAPK signaling cascadesCervical ripeningProgesterone withdrawalCOX inhibitorsImmunohistochemical stainingChorioamnionitisFetal membrane ruptureNF-kBProstaglandin productionPGF2α productionEffects of tibolone and its metabolites on prolactin and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells
Guzel E, Buchwalder L, Basar M, Kayisli U, Ocak N, Bozkurt I, Lockwood CJ, Schatz F. Effects of tibolone and its metabolites on prolactin and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells. Gynecological Endocrinology 2015, 31: 414-418. PMID: 25856298, DOI: 10.3109/09513590.2015.1014788.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternContraceptive Agents, FemaleDexamethasoneEndometriumEnzyme-Linked Immunosorbent AssayEstradiolEstrenesEstrogen Receptor ModulatorsEstrogensFemaleFuransGlucocorticoidsHormone AntagonistsHumansInsulin-Like Growth Factor Binding Protein 1Medroxyprogesterone AcetateMifepristoneNorpregnanesNorpregnenesProlactinReal-Time Polymerase Chain ReactionRNA, MessengerStromal CellsConceptsHuman endometrial stromal cellsCultured human endometrial stromal cellsInsulin-like growth factorEndometrial stromal cellsIGFBP-1RT/PCRTibolone administrationStromal cellsGrowth factorEffects of tiboloneProlactin expressionProtein-1 expressionEndometrial atrophyTibolone metabolitesWestern blot analysisEndometrial bleedingMedroxyprogesterone acetateProlactin levelsTiboloneSpecific ELISAChronic effectsProlactin outputProtein 1ELISA resultsBlot analysis
2014
Interferon-γ Protects First-Trimester Decidual Cells against Aberrant Matrix Metalloproteinases 1, 3, and 9 Expression in Preeclampsia
Lockwood CJ, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Murk W, Wang J, De Paz N, Shapiro JP, Masch RJ, Semerci N, Huang SJ, Schatz F. Interferon-γ Protects First-Trimester Decidual Cells against Aberrant Matrix Metalloproteinases 1, 3, and 9 Expression in Preeclampsia. American Journal Of Pathology 2014, 184: 2549-2559. PMID: 25065683, PMCID: PMC4188280, DOI: 10.1016/j.ajpath.2014.05.025.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternDeciduaEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryInterferon-gammaKiller Cells, NaturalMacrophagesMatrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix Metalloproteinase 9Matrix Metalloproteinases, SecretedPre-EclampsiaPregnancyPregnancy Trimester, FirstReal-Time Polymerase Chain ReactionConceptsMitogen-activated protein kinaseP38 mitogen-activated protein kinaseMitogen-activated protein kinase phosphorylationP38 mitogen-activated protein kinase phosphorylationExtracellular matrix proteinsProtein kinase phosphorylationHuman first trimester decidual cellsProtein kinaseReal-time quantitative RT-PCREVT invasionKinase phosphorylationQuantitative RT-PCRMatrix proteinsProteolytic cascadeDecidual cellsIntegrin receptorsExtravillous trophoblastsHuman extravillous trophoblastsIncomplete spiral arteryMMP-9Protein levelsProtein expressionMMP-1MMP-2Fibrillar collagen