2015
Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding
Kayisli O, Kayisli UA, Basar M, Semerci N, Schatz F, Lockwood CJ. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding. PLOS ONE 2015, 10: e0137855. PMID: 26436918, PMCID: PMC4593551, DOI: 10.1371/journal.pone.0137855.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsAbnormal uterine bleedingEndometrial stromal cellsMedroxyprogesterone acetateGuinea pigsUterine bleedingCultured human endometrial stromal cellsStromal cellsGlandular cellsProgestin only contraceptivesEndometrial blood flowOvariectomized guinea pigsMajor side effectsEffective family planning methodsGlucocorticoid receptor activationGR transcriptional activityFragile blood vesselsFamily planning methodsIngenuity Pathway AnalysisFKBP51 expressionFunctional withdrawalMicroarray resultsOnly contraceptivesGlucocorticoid withdrawalEndometrial inflammationEffects of tibolone and its metabolites on prolactin and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells
Guzel E, Buchwalder L, Basar M, Kayisli U, Ocak N, Bozkurt I, Lockwood CJ, Schatz F. Effects of tibolone and its metabolites on prolactin and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells. Gynecological Endocrinology 2015, 31: 414-418. PMID: 25856298, DOI: 10.3109/09513590.2015.1014788.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternContraceptive Agents, FemaleDexamethasoneEndometriumEnzyme-Linked Immunosorbent AssayEstradiolEstrenesEstrogen Receptor ModulatorsEstrogensFemaleFuransGlucocorticoidsHormone AntagonistsHumansInsulin-Like Growth Factor Binding Protein 1Medroxyprogesterone AcetateMifepristoneNorpregnanesNorpregnenesProlactinReal-Time Polymerase Chain ReactionRNA, MessengerStromal CellsConceptsHuman endometrial stromal cellsCultured human endometrial stromal cellsInsulin-like growth factorEndometrial stromal cellsIGFBP-1RT/PCRTibolone administrationStromal cellsGrowth factorEffects of tiboloneProlactin expressionProtein-1 expressionEndometrial atrophyTibolone metabolitesWestern blot analysisEndometrial bleedingMedroxyprogesterone acetateProlactin levelsTiboloneSpecific ELISAChronic effectsProlactin outputProtein 1ELISA resultsBlot analysis
2012
Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis
Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis. Reproductive Sciences 2012, 19: 572-579. PMID: 22267540, PMCID: PMC3439122, DOI: 10.1177/1933719111430998.Peer-Reviewed Original ResearchConceptsCultured endometriotic cellsMonocyte chemotactic protein-1 expressionChemotactic protein-1 expressionMCP-1 productionEndometriotic cellsProtein-1 expressionEndometriotic implantsMouse modelMCP-1 messenger RNA expressionExerts anti-inflammatory effectsAnti-inflammatory effectsEffect of statinsAnti-inflammatory propertiesMCP-1 expressionMevalonate pathwayDose-dependent inhibitionNude mouse modelMessenger RNA expressionDose-dependent mannerEctopic endometriumEndometrial cellsPeritoneal surfaceStatinsPotential treatmentInhibitory effect
2010
Preeclampsia-related increase of interleukin-11 expression in human decidual cells
Basar M, Yen CF, Buchwalder LF, Murk W, Huang SJ, Godlewski K, Kocamaz E, Arda O, Schatz F, Lockwood CJ, Kayisli UA. Preeclampsia-related increase of interleukin-11 expression in human decidual cells. Reproduction 2010, 140: 605-612. PMID: 20668109, PMCID: PMC3795512, DOI: 10.1530/rep-10-0263.Peer-Reviewed Original ResearchMeSH KeywordsAdultDeciduaEstradiolFemaleHumansImidazolesImmunohistochemistryInterleukin-11Interleukin-1betaNaphthalenesNF-kappa BP38 Mitogen-Activated Protein KinasesPre-EclampsiaPregnancyProtein Kinase CPyridinesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricTumor Necrosis Factor-alphaConceptsFirst trimester decidual cellsDecidual cellsPlacental sectionsLeukocyte-free first trimester decidual cellsGestational age-matched controlsProtein kinase CMaternal-placental interfaceUteroplacental blood flowPathogenesis of preeclampsiaAnti-inflammatory processesCultured decidual cellsTumor necrosis factorAge-matched controlsHuman decidual cellsQuantitative RT-PCRSystemic inflammationNecrosis factorPreeclampsiaBlood flowP38 MAP kinaseIL11 expressionNuclear factorStimulatory effectIL11RT-PCR