2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal models
2021
Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model
Wu X, Ulumben A, Long S, Katagiri W, Wilks M, Yuan H, Cortese B, Yang C, Kashiwagi S, Choi H, Normandin M, Fakhri G, Zaman R. Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model. Biomolecules 2021, 11: 1753. PMID: 34944397, PMCID: PMC8698491, DOI: 10.3390/biom11121753.Peer-Reviewed Original Research
2020
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques
Guehl N, Ramos-Torres K, Linnman C, Moon S, Dhaynaut M, Wilks M, Han P, Ma C, Neelamegam R, Zhou Y, Popko B, Correia J, Reich D, Fakhri G, Herscovitch P, Normandin M, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1721-1733. PMID: 33090071, PMCID: PMC8221756, DOI: 10.1177/0271678x20963404.Peer-Reviewed Original ResearchConceptsFocal brain injuryMyelin repair therapyContributions of demyelinationDrivers of disabilityImaging demyelinationBrain injuryMeasurements of molecular changesTool's sensitivity to changesLower myelin contentDemyelinating lesionsNeuronal conductionImpaired conductionDemyelinationBrain penetrationGold standardRhesus macaquesInjured areaMultiple sclerosisMolecular changesMyelin sheathNeurological diseasesHigh metabolic stabilityMRI methodsMRIInjury
2018
Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling
Argus J, Wilks M, Zhou Q, Hsieh W, Khialeeva E, Hoi X, Bui V, Xu S, Yu A, Wang E, Herschman H, Williams K, Bensinger S. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Reports 2018, 25: 2919-2934.e8. PMID: 30517876, PMCID: PMC6432944, DOI: 10.1016/j.celrep.2018.11.041.Peer-Reviewed Original ResearchConceptsFatty acid metabolismHomeostasis of fatty acidsCellular fatty acid contentCellular fatty acid metabolismAcid metabolismMovement of fatty acidsPolyunsaturated fatty acid poolStable isotope labelingFatty acidsFatty acid homeostasisElongation pathwayFatty acid poolAcid homeostasisMetabolic stepsContribution of synthesisAcid poolPro-inflammatory stimuliFatty acid contentIsotope labelingInflammatory signalingAcid contentMetabolismCellsElongationAcid
2017
Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions
Sîrbulescu R, Boehm C, Soon E, Wilks M, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin M, Fakhri G, Orgill D, Sluder A, Poznansky M. Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair And Regeneration 2017, 25: 774-791. PMID: 28922523, PMCID: PMC5760362, DOI: 10.1111/wrr.12584.Peer-Reviewed Original ResearchConceptsB cell treatmentB cellsKinetics of neutrophil infiltrationImmune cell populationsNaive B cellsWild-type miceSaline-treated controlsMature B cellsGrowth-associated protein 43Wound healingIncreased collagen depositionDiabetic murine woundsObese diabetic micePro-healing responseIncreased fibroblast proliferationWound granulation tissueT cellsIncreased relative expressionNeutrophil infiltrationLive B cellsScar sizeDiabetic miceDecreased apoptosisTopical applicationMMP2 expressionApplication of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals
Zanni M, Toribio M, Wilks M, Lu M, Burdo T, Walker J, Autissier P, Foldyna B, Stone L, Martin A, Cope F, Abbruzzese B, Brady T, Hoffmann U, Williams K, El-Fakhri G, Grinspoon S. Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals. The Journal Of Infectious Diseases 2017, 215: 1264-1269. PMID: 28204544, PMCID: PMC5853590, DOI: 10.1093/infdis/jix095.Peer-Reviewed Original ResearchMeSH KeywordsAortaAtherosclerosisCase-Control StudiesCross-Sectional StudiesDextransHIV InfectionsHumansLectins, C-TypeLymph NodesMacrophagesMaleMannansMannose ReceptorMannose-Binding LectinsMiddle AgedPlaque, AtheroscleroticRadiopharmaceuticalsReceptors, Cell SurfaceRegression AnalysisSingle Photon Emission Computed Tomography Computed TomographyTechnetium Tc 99m PentetateUnited StatesConceptsSingle-photon emission computed tomography/computed tomographyFirst-in-human dataNon-HIV-infected subjectsAortic plaque volumeHIV-infected subjectsHIV-infected individualsMacrophages ex vivoComputed tomographic angiographyCD206+ macrophagesTomography/computed tomographyTomographic angiographyImaging techniquesTechnetium TcHIV statusPlaque volumeCardiovascular diseaseHIVImaging strategiesCD206In vivo applicationsSubjectsTilmanoceptAngiographyMacrophagesTomography
2015
Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models
Wilks M, Normandin M, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten D, Fakhri G, Josephson L. Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models. Bioconjugate Chemistry 2015, 26: 1061-1069. PMID: 25971846, PMCID: PMC5378316, DOI: 10.1021/acs.bioconjchem.5b00213.Peer-Reviewed Original Research
2014
Improved Modeling of In Vivo Kinetics of Slowly Diffusing Radiotracers for Tumor Imaging
Wilks M, Knowles S, Wu A, Huang S. Improved Modeling of In Vivo Kinetics of Slowly Diffusing Radiotracers for Tumor Imaging. Journal Of Nuclear Medicine 2014, 55: 1539-1544. PMID: 24994929, PMCID: PMC4334373, DOI: 10.2967/jnumed.114.140038.Peer-Reviewed Original Research