Assessing the interactions between radiotherapy and antitumour immunity
Grassberger C, Ellsworth S, Wilks M, Keane F, Loeffler J. Assessing the interactions between radiotherapy and antitumour immunity. Nature Reviews Clinical Oncology 2019, 16: 729-745. PMID: 31243334, DOI: 10.1038/s41571-019-0238-9.Peer-Reviewed Original ResearchMeSH KeywordsCombined Modality TherapyHumansImmune SystemImmunotherapyNeoplasmsPrecision MedicineRadiotherapyConceptsImmune checkpoint inhibitorsCheckpoint inhibitorsIntroduction of immune checkpoint inhibitorsTherapy-induced immune responsesLong-term tumor controlImmune responsePre-existing immune responsesImmune response to radiotherapyInteraction of immunotherapyResponse to radiotherapyAdvanced-stage diseaseRadiation-induced immunosuppressionImmune cell dynamicsSite of diseaseIndividualized treatment approachPatient levelAntitumour immunityRadiotherapy regimensTumor controlTreatment of cancerIncrease response ratesRadiotherapyImmunotherapySerum biomarkersClinical data