2024
Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH.
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH. AIDS 2024 PMID: 38905489, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesis
2022
Increased Macrophage-Specific Arterial Infiltration Relates to Noncalcified Plaque and Systemic Immune Activation in People With Human Immunodeficiency Virus
Toribio M, Wilks M, Hedgire S, Lu M, Cetlin M, Wang M, Alhallak I, Durbin C, White K, Wallis Z, Schnittman S, Stanley T, El-Fakhri G, Lee H, Autissier P, Zanni M, Williams K, Grinspoon S. Increased Macrophage-Specific Arterial Infiltration Relates to Noncalcified Plaque and Systemic Immune Activation in People With Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2022, 226: 1823-1833. PMID: 35856671, PMCID: PMC10205602, DOI: 10.1093/infdis/jiac301.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAtherosclerotic cardiovascular diseaseAortic plaque volumeSystemic immune activationArterial infiltrationImmune activationImmunodeficiency virusPlaque volumeHistory of clinical ASCVDCD4+/CD8+ T-cell ratioHuman immunodeficiency virus statusCD8+ T cellsMarkers of immune activationClinical atherosclerotic cardiovascular diseasePersistent immune activationT cell ratioAtherosclerotic cardiovascular disease riskT cellsImmune phenotypeNoncalcified plaqueSystemic markersASCVD riskPWHCardiovascular diseaseUptake volume