2018
Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling
Argus J, Wilks M, Zhou Q, Hsieh W, Khialeeva E, Hoi X, Bui V, Xu S, Yu A, Wang E, Herschman H, Williams K, Bensinger S. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Reports 2018, 25: 2919-2934.e8. PMID: 30517876, PMCID: PMC6432944, DOI: 10.1016/j.celrep.2018.11.041.Peer-Reviewed Original ResearchConceptsFatty acid metabolismHomeostasis of fatty acidsCellular fatty acid contentCellular fatty acid metabolismAcid metabolismMovement of fatty acidsPolyunsaturated fatty acid poolStable isotope labelingFatty acidsFatty acid homeostasisElongation pathwayFatty acid poolAcid homeostasisMetabolic stepsContribution of synthesisAcid poolPro-inflammatory stimuliFatty acid contentIsotope labelingInflammatory signalingAcid contentMetabolismCellsElongationAcid
2013
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Williams K, Argus J, Zhu Y, Wilks M, Marbois B, York A, Kidani Y, Pourzia A, Akhavan D, Lisiero D, Komisopoulou E, Henkin A, Soto H, Chamberlain B, Vergnes L, Jung M, Torres J, Liau L, Christofk H, Prins R, Mischel P, Reue K, Graeber T, Bensinger S. An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity. Cancer Research 2013, 73: 2850-2862. PMID: 23440422, PMCID: PMC3919498, DOI: 10.1158/0008-5472.can-13-0382-t.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell Line, TumorCell ProliferationFatty Acid SynthasesGene Expression ProfilingGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Inbred NODModels, StatisticalNeoplasm TransplantationNeoplasmsSignal TransductionStearoyl-CoA DesaturaseSterolsConceptsSterol regulatory element-binding proteinsFatty acid synthesisSREBP activityCellular growthFatty acid poolKey transcriptional regulatorCancer cellsFatty acid desaturationAcid synthesisAcid poolElement-binding proteinMetabolic flux analysisTranscriptional regulatorsLipid biosynthesisNovel mechanistic explanationStearoyl-CoA desaturase-1Fatty acid synthase activityCancer metabolismCancer cell growthSignaling AxisCell growthFlux analysisSynthase activityDesaturase 1Lipid profiling