2020
Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects
Higgins-Chen AT, Boks MP, Vinkers CH, Kahn RS, Levine ME. Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects. Biological Psychiatry 2020, 88: 224-235. PMID: 32199607, PMCID: PMC7368835, DOI: 10.1016/j.biopsych.2020.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAgingBiomarkersClozapineDNA MethylationEpigenesis, GeneticHumansMaleNeoplasmsSchizophreniaConceptsAge-associated proteinsEpigenetic clocksDNA methylation data setsMethylation data setsEpigenetic ageing biomarkersReduced cancer riskCD8 T cellsBody mass indexLong-term outcomesHorvath's epigenetic clockLower cancer ratesDNA methylationDNA methylation predictorsBiological age differencesMitotic clockMitotic divisionAge clocksCause mortalityNatural killerMass indexEarly mortalityMedication dataSZ casesClozapine's effectIncreased Mortality
2015
A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans
Levine ME, Crimmins EM. A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans. The Journals Of Gerontology Series A 2015, 71: 703-712. PMID: 26355015, PMCID: PMC4888382, DOI: 10.1093/gerona/glv141.Peer-Reviewed Original ResearchConceptsFunctional interaction networkSingle nucleotide polymorphismsStress resistanceNucleotide polymorphismsInteraction networksGenome-wide association studiesPathway analysisAssociation studiesPolygenic risk scoresNetworks AssociatedBiological networksHuman longevityUnique phenotypeHuman agingGenesPolymorphismLongevityPhenotypeInnate resilienceRisk scoreAge 52Threefold increasePathwayWeighted polygenic risk scoreResistance
2014
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population. Cell Metabolism 2014, 19: 407-417. PMID: 24606898, PMCID: PMC3988204, DOI: 10.1016/j.cmet.2014.02.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsBreast NeoplasmsCarrier ProteinsCross-Sectional StudiesDiabetes MellitusDiet, Protein-RestrictedFemaleFollow-Up StudiesHumansInsulin-Like Growth Factor ILongevityMaleMelanomaMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMiddle AgedNeoplasmsProportional Hazards ModelsSignal TransductionConceptsHigh protein intakeOverall mortalityProtein intakeCancer death riskProgression of breastLow protein intakeLow-protein dietHigh protein consumptionDiabetes mortalityAge-related diseasesDeath riskProtein restrictionIGF-1Melanoma tumorsMortalityMouse studiesOlder populationProtein dietOlder adultsIntakeMajor reductionProtein consumptionCancerLow proteinAge