Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population. Cell Metabolism 2014, 19: 407-417. PMID: 24606898, PMCID: PMC3988204, DOI: 10.1016/j.cmet.2014.02.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsBreast NeoplasmsCarrier ProteinsCross-Sectional StudiesDiabetes MellitusDiet, Protein-RestrictedFemaleFollow-Up StudiesHumansInsulin-Like Growth Factor ILongevityMaleMelanomaMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMiddle AgedNeoplasmsProportional Hazards ModelsSignal TransductionConceptsHigh protein intakeOverall mortalityProtein intakeCancer death riskProgression of breastLow protein intakeLow-protein dietHigh protein consumptionDiabetes mortalityAge-related diseasesDeath riskProtein restrictionIGF-1Melanoma tumorsMortalityMouse studiesOlder populationProtein dietOlder adultsIntakeMajor reductionProtein consumptionCancerLow proteinAge