Extending human healthspan and longevity: a symposium report
DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Annals Of The New York Academy Of Sciences 2021, 1507: 70-83. PMID: 34498278, PMCID: PMC10231756, DOI: 10.1111/nyas.14681.Peer-Reviewed Original ResearchConceptsAge-related diseasesEarly-stage clinical trialsField of geroscienceReduction of morbidityBiological agingEnd of lifeClinical trialsNovel agentsClinical developmentGeroscience hypothesisFDA approvalDrug evaluationMultiple disordersTherapyDiseaseSymposium reportConcept studyHuman healthspanHealthspanAging processSignificant barriersMorbidityDysfunctionAgingTrialsBiological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants
Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME. Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. The Journals Of Gerontology Series A 2021, 76: e133-e141. PMID: 33684206, PMCID: PMC7989601, DOI: 10.1093/gerona/glab060.Peer-Reviewed Original ResearchConceptsCOVID-19 severity outcomeCOVID-19 severityDiseases/conditionsAge-related comorbid conditionsCOVID-19-related mortalityPrevalent chronic diseasesCOVID-19 infectionBiggest risk factorCOVID-19Severity outcomesUK Biobank participantsLogistic regression modelsComorbid conditionsTest positivityRisk factorsChronic diseasesInpatient settingFurther adjustmentSymptom severityEarly pandemicBiobank participantsDisease prevalenceAgeSeverityCOVID-19 pandemic