2015
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older
Arpawong TE, Lee J, Phillips DF, Crimmins EM, Levine ME, Prescott CA. Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. Behavior Genetics 2015, 46: 72-88. PMID: 26330209, PMCID: PMC4720538, DOI: 10.1007/s10519-015-9740-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesDepressionDepressive DisorderEthnicityFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansLife Change EventsMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsDepressive symptomsU.S. population-based studyRecent stressOlder adultsStress-diathesis hypothesisPopulation-based studySerotonin transporter gene promoter regionSingle nucleotide polymorphismsDepressive symptom levelsPopulation-based sampleAdults age 50Race/ethnicityAge 50Repeated-measures designSerotonin transporter polymorphismDepressive symptomatologySymptomsOlder individualsSymptom levelsReverse causationTransporter polymorphismMeasures studyDifferential effectsShort alleleStressful events
2014
A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults
Levine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J. A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults. Biodemography And Social Biology 2014, 60: 199-211. PMID: 25343367, PMCID: PMC4298361, DOI: 10.1080/19485565.2014.952705.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDepressive Disorder, MajorFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiddle AgedMultifactorial InheritanceOdds RatioRisk FactorsConceptsHigher CESD scoresPolygenic risk scoresCESD scoresDepressive symptomsEpidemiological Studies Depression Scale scoreWeighted polygenic risk scoreLogistic regression modelsReplication sampleMultinomial logistic regression modelsRisk scoreScale scoreDiscovery setIndividual susceptibilitySymptomsOlder adultsAnalytic sampleGenetic riskSingle nucleotide polymorphismsScoresRetirement StudyRegression modelsDepressionPercent increaseAssociationHigh levels