2019
Changing Disease Prevalence, Incidence, and Mortality Among Older Cohorts: The Health and Retirement Study
Crimmins EM, Zhang YS, Kim JK, Levine ME. Changing Disease Prevalence, Incidence, and Mortality Among Older Cohorts: The Health and Retirement Study. The Journals Of Gerontology Series A 2019, 74: s21-s26. PMID: 31724057, PMCID: PMC6853787, DOI: 10.1093/gerona/glz075.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHeart diseaseOlder cohortDisease prevalencePopulation healthPrevalence of cancerPrevalence of peopleYounger cohortsRetirement StudyStart of observationCardiovascular conditionsAge 70CohortOlder personsInfarctionPrevalenceIncidenceDeath rateStrokeDiseaseImportant signCancerMortalityHealthDiabetes
2015
DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative
Levine ME, Hosgood HD, Chen B, Absher D, Assimes T, Horvath S. DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Aging 2015, 7: 690-700. PMID: 26411804, PMCID: PMC4600626, DOI: 10.18632/aging.100809.Peer-Reviewed Original ResearchConceptsIntrinsic epigenetic age accelerationWomen's Health InitiativeLung cancer incidenceLung cancer susceptibilityLung cancerHealth initiativesCancer incidenceCox proportional hazards modelCancer susceptibilityLung cancer casesProportional hazards modelCurrent smokersAge-related declineAge-associated diseasesAge-related diseasesFuture onsetCancer casesCigarette smokeHazards modelUseful biomarkerEpigenetic age accelerationCandidate biomarkersOlder individualsDNA methylation ageGenotoxic carcinogens