2020
Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women’s Health Initiative (WHI)
Thurston RC, Carroll JE, Levine M, Chang Y, Crandall C, Manson JE, Pal L, Hou L, Shadyab AH, Horvath S. Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women’s Health Initiative (WHI). The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa081. PMID: 32080740, PMCID: PMC7069347, DOI: 10.1210/clinem/dgaa081.Peer-Reviewed Original ResearchConceptsVasomotor symptomsWomen's Health InitiativePostmenopausal womenHealth initiativesMenopausal vasomotor symptomsSevere hot flashesBody mass indexAdverse health indicatorsPoor health outcomesYears of ageBiological agingRace/ethnicityAccelerated Epigenetic AgingHormone therapyHot flashesMass indexMenopausal symptomsSleep disturbancesEpigenetic agingEarly deathDNAm PhenoAgeHealth outcomesTiming groupsDNAm GrimAgeSymptoms
2017
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging 2017, 9: 419-437. PMID: 28198702, PMCID: PMC5361673, DOI: 10.18632/aging.101168.Peer-Reviewed Original ResearchConceptsIntrinsic epigenetic age accelerationExtrinsic epigenetic age accelerationModerate alcohol consumptionMetabolic syndromeLifestyle factorsAlcohol consumptionEpigenetic age accelerationHealth initiativesItalian cohort studyPostmenopausal female participantsFirst-line medicationWomen's Health InitiativeBlood carotenoid levelsType 2 diabetesAge accelerationAge-related functional declineHealth-related outcomesEpigenetic clock analysisFemale participantsIndicator of fruitCause mortalityCohort studyPoultry intakeChronic conditionsFish intake
2016
Menopause accelerates biological aging
Levine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, Bandinelli S, Salfati E, Manson JE, Quach A, Kusters CD, Kuh D, Wong A, Teschendorff AE, Widschwendter M, Ritz BR, Absher D, Assimes TL, Horvath S. Menopause accelerates biological aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9327-9332. PMID: 27457926, PMCID: PMC4995944, DOI: 10.1073/pnas.1604558113.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationBilateral oophorectomyBuccal epitheliumAge accelerationHealth initiativesMedical Research Council National SurveyMenopausal hormone therapyWomen's Health InitiativeEpigenetic clock analysisHigher epigenetic ageMendelian randomization approachMendelian randomization analysisEpigenetic ageHormone therapyEarly menopauseParkinson's diseaseMenopauseReproductive agingSignificant associationLarger studyBloodRandomization analysisDiseaseAgeEpithelium
2015
DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative
Levine ME, Hosgood HD, Chen B, Absher D, Assimes T, Horvath S. DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Aging 2015, 7: 690-700. PMID: 26411804, PMCID: PMC4600626, DOI: 10.18632/aging.100809.Peer-Reviewed Original ResearchConceptsIntrinsic epigenetic age accelerationWomen's Health InitiativeLung cancer incidenceLung cancer susceptibilityLung cancerHealth initiativesCancer incidenceCox proportional hazards modelCancer susceptibilityLung cancer casesProportional hazards modelCurrent smokersAge-related declineAge-associated diseasesAge-related diseasesFuture onsetCancer casesCigarette smokeHazards modelUseful biomarkerEpigenetic age accelerationCandidate biomarkersOlder individualsDNA methylation ageGenotoxic carcinogens