2022
Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease
Thrush KL, Bennett DA, Gaiteri C, Horvath S, Dyck CHV, Higgins-Chen AT, Levine ME. Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease. Aging 2022, 14: 5641-5668. PMID: 35907208, PMCID: PMC9365556, DOI: 10.18632/aging.204196.Peer-Reviewed Original ResearchConceptsDisease risk increasesBrain agingAD brain tissueΕ4 carrier statusClinical AD dementiaMultiple brain regionsEpigenetic alterationsReligious Orders StudyAD dementiaTest-retest reliabilityCortical samplesAD riskEpigenetic age accelerationSubcortical regionsPathologic ADAlzheimer's diseaseBrain regionsBrain tissueEpigenetic clocksCarrier statusStrong associationRush MemoryAge accelerationRisk increaseAging Project
2014
A comparison of methods for assessing mortality risk
Levine ME, Crimmins EM. A comparison of methods for assessing mortality risk. American Journal Of Human Biology 2014, 26: 768-776. PMID: 25088793, PMCID: PMC4286244, DOI: 10.1002/ajhb.22595.Peer-Reviewed Original ResearchConceptsFramingham risk scoreDisease-specific mortalityRisk scoreAllostatic loadBiological ageNutrition Examination Survey IIICox proportional hazards modelStratified age groupsStrong associationExamination Survey IIIProportional hazards modelParticipants ages 50CVD mortalityPerson yearsCancer mortalityNational HealthStudy populationMortality riskAge 50Hazards modelAge 30Age groupsMortalityAge rangeSurvey III