Loneliness, eudaimonia, and the human conserved transcriptional response to adversity
Cole SW, Levine ME, Arevalo JM, Ma J, Weir DR, Crimmins EM. Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. Psychoneuroendocrinology 2015, 62: 11-17. PMID: 26246388, PMCID: PMC4637182, DOI: 10.1016/j.psyneuen.2015.07.001.Peer-Reviewed Original ResearchConceptsRisk factorsBehavioral health risk factorsCommunity-dwelling older adultsPeripheral blood samplesPro-inflammatory genesHealth risk factorsSocial isolationMixed effect linear model analysesChronic social adversityCTRA gene expressionStrength of associationGene expressionPsychological resilience factorsResilience factorsAdversity factorsBlood samplesIncreased expressionMeasures of lonelinessOlder adultsSocial adversityAnxiety symptomsUS HealthLinear model analysisRetirement StudyHealth risks