2021
The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study
Schmitz LL, Zhao W, Ratliff SM, Goodwin J, Miao J, Lu Q, Guo X, Taylor KD, Ding J, Liu Y, Levine M, Smith JA. The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study. Epigenetics 2021, 17: 589-611. PMID: 34227900, PMCID: PMC9235889, DOI: 10.1080/15592294.2021.1939479.Peer-Reviewed Original ResearchConceptsMulti-Ethnic StudySocioeconomic statusSocioeconomic gradientFaster biological agingEpigenetic agingBiological agingRetirement StudyAlcohol consumptionHealth behaviorsSignificant associationDisease riskSES gradientOlder adultsGenetic riskPolygenic riskEpigenetic clocksAtherosclerosisSES measuresAssociationInconsistent resultsRobust associationRiskMultiple tissues
2019
Changing Disease Prevalence, Incidence, and Mortality Among Older Cohorts: The Health and Retirement Study
Crimmins EM, Zhang YS, Kim JK, Levine ME. Changing Disease Prevalence, Incidence, and Mortality Among Older Cohorts: The Health and Retirement Study. The Journals Of Gerontology Series A 2019, 74: s21-s26. PMID: 31724057, PMCID: PMC6853787, DOI: 10.1093/gerona/glz075.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHeart diseaseOlder cohortDisease prevalencePopulation healthPrevalence of cancerPrevalence of peopleYounger cohortsRetirement StudyStart of observationCardiovascular conditionsAge 70CohortOlder personsInfarctionPrevalenceIncidenceDeath rateStrokeDiseaseImportant signCancerMortalityHealthDiabetesAssociations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseasePhenotypic agingUS older adultsSelf-reported circumstancesRetirement StudyLife course circumstancesAssociation of geneticMorbidity riskMultivariable associationsPotential policy targetsRetrospective natureAdulthood circumstancesPhenotypic AgeAdulthood adversityGenetic predispositionHealth behaviorsSocioenvironmental circumstancesUS populationOlder adultsPotential interventionsDisadvantaged subpopulationsGenetic riskGenetic scoreUS Health
2018
Predictors and implications of accelerated cognitive aging
Levine ME, Harrati A, Crimmins EM. Predictors and implications of accelerated cognitive aging. Biodemography And Social Biology 2018, 64: 83-101. PMID: 31007841, PMCID: PMC6469682, DOI: 10.1080/19485565.2018.1552513.Peer-Reviewed Original ResearchConceptsCognitive ageCognitive agingCognitive declineNon-demented older adultsPathological cognitive declineAge-related declineIndividual differencesCognitive slopesOlder adultsLongitudinal studyComposite measureRetirement StudyAPOE ε4Performance testsDementia transitionSubsequent dementiaDementiaMeasuresRate of declineParticipantsAgingDeclineDifferent conclusionsRace/ethnicityAbsolute levels
2015
Loneliness, eudaimonia, and the human conserved transcriptional response to adversity
Cole SW, Levine ME, Arevalo JM, Ma J, Weir DR, Crimmins EM. Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. Psychoneuroendocrinology 2015, 62: 11-17. PMID: 26246388, PMCID: PMC4637182, DOI: 10.1016/j.psyneuen.2015.07.001.Peer-Reviewed Original ResearchConceptsRisk factorsBehavioral health risk factorsCommunity-dwelling older adultsPeripheral blood samplesPro-inflammatory genesHealth risk factorsSocial isolationMixed effect linear model analysesChronic social adversityCTRA gene expressionStrength of associationGene expressionPsychological resilience factorsResilience factorsAdversity factorsBlood samplesIncreased expressionMeasures of lonelinessOlder adultsSocial adversityAnxiety symptomsUS HealthLinear model analysisRetirement StudyHealth risks
2014
A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults
Levine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J. A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults. Biodemography And Social Biology 2014, 60: 199-211. PMID: 25343367, PMCID: PMC4298361, DOI: 10.1080/19485565.2014.952705.Peer-Reviewed Original ResearchConceptsHigher CESD scoresPolygenic risk scoresCESD scoresDepressive symptomsEpidemiological Studies Depression Scale scoreWeighted polygenic risk scoreLogistic regression modelsReplication sampleMultinomial logistic regression modelsRisk scoreScale scoreDiscovery setIndividual susceptibilitySymptomsOlder adultsAnalytic sampleGenetic riskSingle nucleotide polymorphismsScoresRetirement StudyRegression modelsDepressionPercent increaseAssociationHigh levels