2022
Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study
Cao X, Ma C, Zheng Z, He L, Hao M, Chen X, Crimmins EM, Gill TM, Levine ME, Liu Z. Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study. EClinicalMedicine 2022, 51: 101548. PMID: 35844770, PMCID: PMC9284373, DOI: 10.1016/j.eclinm.2022.101548.Peer-Reviewed Original ResearchDisease Research CenterDisadvantaged subpopulationsAdulthood circumstancesAlzheimer's Disease Research CenterRetirement Longitudinal StudyFunctional agingLife course circumstancesAdvancing Translational SciencesRetrospective studyChronic diseasesGeneral linear regression modelHealth gapChina HealthBiomarker collectionOlder adultsLater lifeNational InstituteLongitudinal studySubpopulationsLinear regression modelsTranslational scienceRegression modelsChildhoodAdvantaged counterpartsHealth
2017
Biological Age, Not Chronological Age, Is Associated with Late-Life Depression
Brown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR. Biological Age, Not Chronological Age, Is Associated with Late-Life Depression. The Journals Of Gerontology Series A 2017, 73: 1370-1376. PMID: 28958059, PMCID: PMC6132120, DOI: 10.1093/gerona/glx162.Peer-Reviewed Original ResearchConceptsLate-life depressionCES-D scoresDepressive symptomsBaseline CES-D scoreBiological ageChronological ageCovariate-adjusted regression modelsOlder biological ageEpidemiologic Studies Depression ScaleSignificant depressive symptomsBody Composition StudyMean chronological ageAge-associated changesNumerous physiological systemsAge-related processesKidney functioningLife depressionDepression ScaleDepression groupBrain disordersHealth AgingLongitudinal associationsSymptomsAgeRegression models
2014
A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults
Levine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J. A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults. Biodemography And Social Biology 2014, 60: 199-211. PMID: 25343367, PMCID: PMC4298361, DOI: 10.1080/19485565.2014.952705.Peer-Reviewed Original ResearchConceptsHigher CESD scoresPolygenic risk scoresCESD scoresDepressive symptomsEpidemiological Studies Depression Scale scoreWeighted polygenic risk scoreLogistic regression modelsReplication sampleMultinomial logistic regression modelsRisk scoreScale scoreDiscovery setIndividual susceptibilitySymptomsOlder adultsAnalytic sampleGenetic riskSingle nucleotide polymorphismsScoresRetirement StudyRegression modelsDepressionPercent increaseAssociationHigh levels