2016
Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study
Carroll JE, Irwin MR, Levine M, Seeman TE, Absher D, Assimes T, Horvath S. Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study. Biological Psychiatry 2016, 81: 136-144. PMID: 27702440, PMCID: PMC5536960, DOI: 10.1016/j.biopsych.2016.07.008.Peer-Reviewed Original ResearchConceptsNaive T cellsWomen's Health Initiative studyDifferentiated T cellsT cellsInsomnia symptomsAge-related morbidityShort sleepSleep durationInitiative studyLarge population-based studyEpigenetic agePopulation-based studyLong sleep durationSymptoms of insomniaImmune senescenceImmune cellsLong sleepAdvanced epigenetic ageCell countSymptomsInfluence riskSleepCross-sectional dataAgeAge acceleration
2015
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older
Arpawong TE, Lee J, Phillips DF, Crimmins EM, Levine ME, Prescott CA. Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. Behavior Genetics 2015, 46: 72-88. PMID: 26330209, PMCID: PMC4720538, DOI: 10.1007/s10519-015-9740-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesDepressionDepressive DisorderEthnicityFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansLife Change EventsMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsDepressive symptomsU.S. population-based studyRecent stressOlder adultsStress-diathesis hypothesisPopulation-based studySerotonin transporter gene promoter regionSingle nucleotide polymorphismsDepressive symptom levelsPopulation-based sampleAdults age 50Race/ethnicityAge 50Repeated-measures designSerotonin transporter polymorphismDepressive symptomatologySymptomsOlder individualsSymptom levelsReverse causationTransporter polymorphismMeasures studyDifferential effectsShort alleleStressful events