A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores
Levine ME, Langfelder P, Horvath S. A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores. Methods In Molecular Biology 2017, 1613: 277-290. PMID: 28849564, PMCID: PMC5998804, DOI: 10.1007/978-1-4939-7027-8_10.Peer-Reviewed Original ResearchConceptsComplex traitsHuman heightCorrelation network analysisPolygenic score methodsPolygenic scoresSNP networkGWAS dataHub genesBiological insightsGenetic markersAllele countsGenetic pleiotropyTraitsGene scoreBiologyNetwork analysisPolygenic risk scoresNetwork-based methodPleiotropyGenesEnvironmental effectsSNPsPathwayLarge proportionDeeper understanding