2017
Genetic architecture of epigenetic and neuronal ageing rates in human brain regions
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S. Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nature Communications 2017, 8: 15353. PMID: 28516910, PMCID: PMC5454371, DOI: 10.1038/ncomms15353.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingBrainBrain MappingCalcium-Binding ProteinsChildChild, PreschoolCognitive DysfunctionDNA MethylationEpigenesis, GeneticFemaleGenome, HumanGenome-Wide Association StudyHumansInfantMaleMiddle AgedNerve Tissue ProteinsNeurodegenerative DiseasesNeuronsQuantitative Trait LociConceptsGenome-wide association studiesCis-expression quantitative trait lociGenome-wide significant lociProportion of neuronsQuantitative trait lociEpigenetic aging ratesDNA methylation-based biomarkersEpigenetic agingMethylation-based biomarkersGenetic architectureTrait lociSignificant lociAssociation studiesBrain regionsAge-related macular degenerationType 2 diabetesAging rateGenesLociHuman brain regionsUlcerative colitisWaist circumferenceMacular degenerationParkinson's diseaseBrain samples
2016
Menopause accelerates biological aging
Levine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, Bandinelli S, Salfati E, Manson JE, Quach A, Kusters CD, Kuh D, Wong A, Teschendorff AE, Widschwendter M, Ritz BR, Absher D, Assimes TL, Horvath S. Menopause accelerates biological aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9327-9332. PMID: 27457926, PMCID: PMC4995944, DOI: 10.1073/pnas.1604558113.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationBilateral oophorectomyBuccal epitheliumAge accelerationHealth initiativesMedical Research Council National SurveyMenopausal hormone therapyWomen's Health InitiativeEpigenetic clock analysisHigher epigenetic ageMendelian randomization approachMendelian randomization analysisEpigenetic ageHormone therapyEarly menopauseParkinson's diseaseMenopauseReproductive agingSignificant associationLarger studyBloodRandomization analysisDiseaseAgeEpithelium