2020
A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin
Levine M, McDevitt RA, Meer M, Perdue K, Di Francesco A, Meade T, Farrell C, Thrush K, Wang M, Dunn C, Pellegrini M, de Cabo R, Ferrucci L. A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin. ELife 2020, 9: e59201. PMID: 33179594, PMCID: PMC7661040, DOI: 10.7554/elife.59201.Peer-Reviewed Original ResearchConceptsTranscriptional factor bindingNovel epigenetic clockEpigenetic signalsIntergenic regionEpigenetic age measuresDNA methylationFactor bindingSequencing dataEpigenetic clocksBiochemical advantagesNetwork analysisH3K9me3H3K27me3HeterochromatinCaloric restrictionRobust biomarkersSubstantial overlapMethylationPhenotypicCpGDNAmAgeBindingMiceClock
2017
A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores
Levine ME, Langfelder P, Horvath S. A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores. Methods In Molecular Biology 2017, 1613: 277-290. PMID: 28849564, PMCID: PMC5998804, DOI: 10.1007/978-1-4939-7027-8_10.Peer-Reviewed Original ResearchConceptsComplex traitsHuman heightCorrelation network analysisPolygenic score methodsPolygenic scoresSNP networkGWAS dataHub genesBiological insightsGenetic markersAllele countsGenetic pleiotropyTraitsGene scoreBiologyNetwork analysisPolygenic risk scoresNetwork-based methodPleiotropyGenesEnvironmental effectsSNPsPathwayLarge proportionDeeper understanding