2022
Epigenetic aging of the demographically non-aging naked mole-rat
Kerepesi C, Meer MV, Ablaeva J, Amoroso VG, Lee SG, Zhang B, Gerashchenko MV, Trapp A, Yim SH, Lu AT, Levine ME, Seluanov A, Horvath S, Park TJ, Gorbunova V, Gladyshev VN. Epigenetic aging of the demographically non-aging naked mole-rat. Nature Communications 2022, 13: 355. PMID: 35039495, PMCID: PMC8763950, DOI: 10.1038/s41467-022-27959-9.Peer-Reviewed Original Research
2018
An epigenetic biomarker of aging for lifespan and healthspan
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. An epigenetic biomarker of aging for lifespan and healthspan. Aging 2018, 10: 573-591. PMID: 29676998, PMCID: PMC5940111, DOI: 10.18632/aging.101414.Peer-Reviewed Original ResearchConceptsEpigenetic biomarkersDNA damage responseTranslational machineryMitochondrial signatureTranscriptional analysisDamage responseNew epigenetic biomarkersMultiple tissuesNovel CpGsInterferon pathwayHealthspanSorted cellsImportant pathwayPathwayCellsLifespanActivationBiological ageDiverse outcomesDNAm PhenoAgeMachineryMajor goalTissueCpGGeroscience