2022
Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study
Cao X, Ma C, Zheng Z, He L, Hao M, Chen X, Crimmins EM, Gill TM, Levine ME, Liu Z. Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study. EClinicalMedicine 2022, 51: 101548. PMID: 35844770, PMCID: PMC9284373, DOI: 10.1016/j.eclinm.2022.101548.Peer-Reviewed Original ResearchDisease Research CenterDisadvantaged subpopulationsAdulthood circumstancesAlzheimer's Disease Research CenterRetirement Longitudinal StudyFunctional agingLife course circumstancesAdvancing Translational SciencesRetrospective studyChronic diseasesGeneral linear regression modelHealth gapChina HealthBiomarker collectionOlder adultsLater lifeNational InstituteLongitudinal studySubpopulationsLinear regression modelsTranslational scienceRegression modelsChildhoodAdvantaged counterpartsHealth
2015
Childhood and later life stressors and increased inflammatory gene expression at older ages
Levine ME, Cole SW, Weir DR, Crimmins EM. Childhood and later life stressors and increased inflammatory gene expression at older ages. Social Science & Medicine 2015, 130: 16-22. PMID: 25658624, PMCID: PMC4394113, DOI: 10.1016/j.socscimed.2015.01.030.Peer-Reviewed Original ResearchConceptsChildhood traumaLow SESPro-inflammatory gene expressionProinflammatory gene expression levelsEarly lifeLater lifeLife health outcomesInflammatory gene expressionLater-life health outcomesHigh riskInflammatory genesAdulthood adversityChildhood healthHealth outcomesAdverse experiencesAdult traumaOlder ageTraumaLate-life stressorsGene expressionElevated levelsFuture healthComposite scoreLife stressorsChildhood