2024
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
Brandhorst S, Levine M, Wei M, Shelehchi M, Morgan T, Nayak K, Dorff T, Hong K, Crimmins E, Cohen P, Longo V. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nature Communications 2024, 15: 1309. PMID: 38378685, PMCID: PMC10879164, DOI: 10.1038/s41467-024-45260-9.Peer-Reviewed Original ResearchConceptsMultiple cardiometabolic risk factorsAssociated with reduced insulin resistanceCardiometabolic risk factorsFasting-mimicking dietImmune system agingRandomized clinical trialsAnalysis of blood samplesAutoimmune cellsBiological ageClinical trialsReduce inflammationMarker changesRisk factorsHepatic fatInsulin resistanceAdult study participantsBlood samplesNormal cellsWeight lossReducing biological ageBiomarker of biological agingDamaged cellsStudy participantsDisease riskAge
2012
The Impact of Insulin Resistance and Inflammation on the Association Between Sarcopenic Obesity and Physical Functioning
Levine ME, Crimmins EM. The Impact of Insulin Resistance and Inflammation on the Association Between Sarcopenic Obesity and Physical Functioning. Obesity 2012, 20: 2101-2106. PMID: 22310233, PMCID: PMC3527629, DOI: 10.1038/oby.2012.20.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryC-reactive proteinInsulin resistancePhysical functioningSarcopenic obesityPhysical functioning problemsMuscle massDifferent body composition phenotypesSerum C-reactive proteinAppendicular skeletal muscle massHomeostasis model assessmentNutrition Examination SurveyCross-sectional studyX-ray absorptiometryBody composition categoriesSkeletal muscle massBody composition phenotypesBody composition measurementsPoisson regression modelsRace/ethnicityNonsarcopenic obesitySarcopenic nonobeseSarcopenic nonobesitySarcopenic obeseSystemic inflammationSarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation?
Levine ME, Crimmins EM. Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation? Current Gerontology And Geriatrics Research 2012, 2012: 826398. PMID: 22611388, PMCID: PMC3352243, DOI: 10.1155/2012/826398.Peer-Reviewed Original ResearchInsulin resistanceBody compositionAdults age 60Muscle massAge 60Non-obese older adultsCognitive functioningCognitive performanceOlder adultsSarcopenic nonobeseSarcopenic obeseHigh CRPSarcopenic obesityWorse cognitive functioningWaist circumferenceMultiple physiological systemsNHANES 1999Abdominal fatObesityMetabolic deregulationLower cognitionAdultsObeseSarcopeniaInflammation