Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S. Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nature Communications 2016, 7: 10561. PMID: 26830004, PMCID: PMC4740877, DOI: 10.1038/ncomms10561.Peer-Reviewed Original ResearchConceptsWide association studyCis-acting effectsDNA methylation levelsAge-related diseasesGWAS analysisSignificant SNPsGene setsMLST8Association studiesEpigenetic clocksMethylation levelsEpigenetic biomarkersGenetic variantsExpression levelsSNPsUnderstanding agingEpigenetic ageTissue ageCerebellar samplesSignificant overlapGWASLociAlzheimer's diseaseClockVariants