2022
Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease
Thrush KL, Bennett DA, Gaiteri C, Horvath S, Dyck CHV, Higgins-Chen AT, Levine ME. Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease. Aging 2022, 14: 5641-5668. PMID: 35907208, PMCID: PMC9365556, DOI: 10.18632/aging.204196.Peer-Reviewed Original ResearchConceptsDisease risk increasesBrain agingAD brain tissueΕ4 carrier statusClinical AD dementiaMultiple brain regionsEpigenetic alterationsReligious Orders StudyAD dementiaTest-retest reliabilityCortical samplesAD riskEpigenetic age accelerationSubcortical regionsPathologic ADAlzheimer's diseaseBrain regionsBrain tissueEpigenetic clocksCarrier statusStrong associationRush MemoryAge accelerationRisk increaseAging Project
2016
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Horvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, Ritz BR, Chen B, Lu AT, Rickabaugh TM, Jamieson BD, Sun D, Li S, Chen W, Quintana-Murci L, Fagny M, Kobor MS, Tsao PS, Reiner AP, Edlefsen KL, Absher D, Assimes TL. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biology 2016, 17: 171. PMID: 27511193, PMCID: PMC4980791, DOI: 10.1186/s13059-016-1030-0.Peer-Reviewed Original ResearchConceptsMortality rateRace/ethnicityRisk factorsTraditional cardio-metabolic risk factorsCardio-metabolic risk factorsCHD risk factorsCoronary heart diseaseCardio-metabolic diseasesEpigenetic clock analysisIntrinsic epigenetic age accelerationAfrican AmericansEpigenetic aging ratesLonger life expectancyCHD outcomesOlder African AmericansHeart diseaseHigh burdenEpigenetic age accelerationLower mortalityDifferent mortality ratesBrain samplesEthnic groupsBrain tissueBloodSocioeconomic differences