2018
An epigenetic biomarker of aging for lifespan and healthspan
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. An epigenetic biomarker of aging for lifespan and healthspan. Aging 2018, 10: 573-591. PMID: 29676998, PMCID: PMC5940111, DOI: 10.18632/aging.101414.Peer-Reviewed Original ResearchConceptsEpigenetic biomarkersDNA damage responseTranslational machineryMitochondrial signatureTranscriptional analysisDamage responseNew epigenetic biomarkersMultiple tissuesNovel CpGsInterferon pathwayHealthspanSorted cellsImportant pathwayPathwayCellsLifespanActivationBiological ageDiverse outcomesDNAm PhenoAgeMachineryMajor goalTissueCpGGeroscience
2017
Contemporaneous Social Environment and the Architecture of Late-Life Gene Expression Profiles
Levine ME, Crimmins EM, Weir DR, Cole SW. Contemporaneous Social Environment and the Architecture of Late-Life Gene Expression Profiles. American Journal Of Epidemiology 2017, 186: 503-509. PMID: 28911009, PMCID: PMC5860329, DOI: 10.1093/aje/kwx147.Peer-Reviewed Original ResearchConceptsTranscriptional responseGene expression programsGene regulation pathwaysBioinformatics-based approachGene expression profilesTranscription factor activationGene expression levelsExpression programsLow socioeconomic statusRegulation pathwaysExpression profilesStress response systemNeuroendocrine signalingFactor activationAntiviral responseExpression levelsSocioeconomic statusPhysiological changesDistinct patternsChronic activationLong-term healthActivationGenesSignalingBiology