2023
Genetic Overlap of Spontaneous Dissection of Either the Thoracic Aorta or the Coronary Arteries
Jeoffrey S, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Genetic Overlap of Spontaneous Dissection of Either the Thoracic Aorta or the Coronary Arteries. The American Journal Of Cardiology 2023, 205: 69-74. PMID: 37591066, DOI: 10.1016/j.amjcard.2023.07.046.Peer-Reviewed Original ResearchConceptsCorresponding molecular pathwaysSpontaneous coronary artery dissectionGenetic overlapMolecular pathwaysGenome-wide association studiesGenetic commonalityGenetic variantsThoracic aortic dissectionIndependent genesGenetic pathwaysSmooth muscle cell functionGenetic methodsAortic dissectionMuscle cell functionAssociation studiesGenetic studiesSudden deathConnective tissue genesGenesTGFβ pathwayCausative genesCoronary artery dissectionTissue genesEarly-onset myocardial infarctionBiologic processesKIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
Velasco J, Li Y, Ziganshin B, Zafar M, Rizzo J, Ma D, Zang H, Kalyanasundaram A, Elefteriades J. KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection. Genes 2023, 14: 252. PMID: 36833179, PMCID: PMC9956195, DOI: 10.3390/genes14020252.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dissectionOdds ratioVariant statusArg allele carriersThoracic aortic dissectionOccurrence of ADAortic sizeArg alleleMarked adverse impactTAA patientsAortic aneurysmClinical assessmentSurgical decisionAllele carriersIncrease riskVariant patientsArg carriersPilot studyDissectionImportant intracellular functionsConfirmatory findingsPatientsAneurysmsPresent study
2022
Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation
Dong H, Liu M, Lou X, Leshnower B, Sun W, Ziganshin B, Zafar M, Elefteriades J. Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation. Applications In Engineering Science 2022, 10: 100101. DOI: 10.1016/j.apples.2022.100101.Peer-Reviewed Original ResearchThoracic aortic dissectionAortic dissectionAortic tissueDissection eventsBicuspid aortic valveUnderlying genetic abnormalitiesHuman aortic tissueHypertensive episodesAortic arch morphologyAortic valveAdvanced ageTissue injuryConnective tissue ingrowthAged animalsAortic wallInciting factorsGenetic abnormalitiesClinical contextArch morphologyDissectionDissected tissuesTissueResponseTissue ingrowthInjury