2021
Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors
Rodart I, Pares M, Mendes A, Accardo C, Martins J, Silva C, Carvalho F, Barreto J, Reis M, Tersariol I, Nader H. Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors. Molecules 2021, 26: 3892. PMID: 34202190, PMCID: PMC8270308, DOI: 10.3390/molecules26133892.Peer-Reviewed Original ResearchConceptsHepatitis C virusAsymptomatic blood donorsLiver fibrosisBlood donorsSerum hyaluronanHCV infectionSerum levelsGGT serum levelsHA serum levelsHCV RNA detectionHCV viral loadProgressive liver diseaseAdvanced liver fibrosisHigher ALT levelsSignificant liver fibrosisNormal ALTHCV viremiaALT levelsAntiviral treatmentAsymptomatic personsBiopsy confirmationHCV samplesLiver biomarkersLiver diseaseViral load
2019
A localized outbreak of Chikungunya virus in Salvador, Bahia, Brazil
Tauro L, Cardoso C, Souza R, Nascimento L, dos Santos D, Campos G, Sardi S, dos Reis O, Reis M, Kitron U, Ribeiro G. A localized outbreak of Chikungunya virus in Salvador, Bahia, Brazil. Memórias Do Instituto Oswaldo Cruz 2019, 114: e180597. PMID: 30843962, PMCID: PMC6396974, DOI: 10.1590/0074-02760180597.Peer-Reviewed Original Research
2016
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil
Azevedo J, Dos Anjos ES, Cordeiro S, Dos Santos M, Escobar E, Lobo P, Carvalho MD, Reis M, Reis J, Campos L. Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil. Journal Of Medical Microbiology 2016, 65: 1164-1170. PMID: 27599851, DOI: 10.1099/jmm.0.000346.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrazilChildChild, PreschoolDrug Resistance, BacterialElectrophoresis, Gel, Pulsed-FieldFemaleGenetic VariationGenotypeHospitalsHumansInfantMaleMeningitis, PneumococcalMicrobial Sensitivity TestsMiddle AgedMolecular EpidemiologyMultilocus Sequence TypingMultiplex Polymerase Chain ReactionPneumococcal VaccinesSerogroupSerotypingStreptococcus pneumoniaeYoung AdultConceptsPost-vaccine periodMulti-locus sequence typing resultsIntroduction of PCV10Non-vaccine serotypesCases of meningitisPneumococcal conjugate vaccineBenefits of vaccinationChildhood vaccination programsAntimicrobial susceptibility testingMulti-locus sequence typingPCV10 introductionPneumococcal meningitisConjugate vaccineReference hospitalSerotype 19AMeningitis casesSerotype 12FVaccination programMore antibioticsSerotype isolatesQuellung reactionE-testStreptococcus pneumoniaeMeningitisSusceptibility testing
2014
HBV/HDV co‐infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
Kay A, da Silva E, Pedreira H, Negreiros S, Lobato C, Braga W, Muwonge R, Dény P, Reis M, Zoulim F, Trepo C, D'Oliveira A, Salcedo J, Schinoni M, Parana R. HBV/HDV co‐infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal Of Viral Hepatitis 2014, 21: 921-924. PMID: 25040045, DOI: 10.1111/jvh.12267.Peer-Reviewed Original Research
2010
Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients
Barbosa C, Goncalves-Santos N, Souza-Ribeiro S, Moura-Neto J, Takahashi D, Silva D, Hurtado-Guerrero A, Reis M, Goncalves M. Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients. Brazilian Journal Of Medical And Biological Research 2010, 43: 705-711. PMID: 20602015, DOI: 10.1590/s0100-879x2010007500062.Peer-Reviewed Original ResearchEvaluating glutathione S‐Transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia
GONCALVES M, NETO J, SOUZA C, MELO P, REIS M. Evaluating glutathione S‐Transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal Of Laboratory Hematology 2010, 32: e49-e56. PMID: 19555437, DOI: 10.1111/j.1751-553x.2009.01169.x.Peer-Reviewed Original ResearchConceptsGSTM1 null genotypeNull genotypeBiomarkers of susceptibilityWhite blood cell countGlutathione S-transferase null genotypeOccurrence of leukopeniaRisk of neutropeniaBlood cell countCase-control studyWhite blood cell deficiencyGlutathione S-transferaseGSTT1 null genotypeOxidative stress productsBlood cell deficiencyGSTM1 genotypeLeukopeniaNormal subjectsCell countPotential biomarkersNeutropeniaGSTT1BiomarkersStress productsRiskSubjects
2008
Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients
Adorno E, Moura-Neto J, Lyra I, Zanette A, Santos L, Seixas M, Reis M, Goncalves M. Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients. Brazilian Journal Of Medical And Biological Research 2008, 41: 95-98. PMID: 18235968, DOI: 10.1590/s0100-879x2008005000002.Peer-Reviewed Original Research
2006
Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
Silva L, Silva M, Rodart I, Lopes G, Costa F, Melo M, Gusmão E, Reis M. Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil. Brazilian Journal Of Medical And Biological Research 2006, 39: 595-602. PMID: 16648896, DOI: 10.1590/s0100-879x2006000500005.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionCandidate blood donorsC virus infectionHD patientsHCV infectionBlood donorsGenotype 1Virus infectionAnti-HCV seroprevalenceAnti-HCV prevalenceHCV genotype distributionAnti-HCV antibodiesHCV genotype 1Chronic liver diseaseTransfusion-transmitted infectionsCross-sectional studyDifferent dialysis centresHCV seroprevalenceChronic hemodialysisHemodialysis populationHCV RNAPositive patientsHemodialysis patientsHCV genotypesLiver disease
2005
HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
Lyra A, Pinho J, Silva L, Sousa L, Saraceni C, Braga E, Pereira J, Zarife M, Reis M, Lyra L, da Silva L, Carrilho F. HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis. Brazilian Journal Of Medical And Biological Research 2005, 38: 767-775. PMID: 15917959, DOI: 10.1590/s0100-879x2005000500015.Peer-Reviewed Original ResearchConceptsAnti-HEV IgMHepatitis AGenotype 1C hepatitisAcute hepatitisAcute viral hepatitis AAnti-HEV IgG antibodiesAcute hepatitis A casesPrevalence of HEVAcute hepatitis AAcute viral hepatitisHepatitis A casesViral hepatitis ATTV genotype 1HEV IgGHGV infectionHGV markersAminotransferase levelsHepatitis EViral hepatitisIgG antibodiesBlood donorsHepatitisHGV isolatesPatients
2003
Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia
Codes L, de Freitas L, Jesus R, Vitvitski L, Silva L, Trepo C, Reis M, Paraná R. Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. The Brazilian Journal Of Infectious Diseases 2003, 7: 409-417. PMID: 14636481, DOI: 10.1590/s1413-86702003000600009.Peer-Reviewed Original ResearchConceptsHepatitis C virusC virusMost patientsSubtype 3aAverage agePositive anti-HCV resultsAnti-HCV resultsNecro-inflammatory activityDevelopment of cirrhosisOutpatient medical recordsSignificant differencesIllicit drug useMETAVIR classificationThyroid dysfunctionYounger patientsHistopathological findingsInflammatory activityLymphoid folliclesEpidemiological characteristicsRNA-HCVGenotype 3Medical recordsSubtype 1bAlcohol consumersGenotype 1
2000
Hepatitis C virus genotypes in a northeastern area of Brazil.
Silva L, Paraná R, Souza S, Berby F, Kay A, Trepó C, Santana N, Cotrim H, Lyra L, Reis M. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal Of Tropical Medicine And Hygiene 2000, 62: 257-60. PMID: 10813481, DOI: 10.4269/ajtmh.2000.62.257.Peer-Reviewed Original ResearchConceptsHepatitis C virusReverse transcription-polymerase chain reactionC virusGenotyping of HCVTranscription-polymerase chain reactionSeropositive serum samplesGenotype-specific primersWarrants further investigationGenotype 3Subtype 1aAlanine aminotransferaseGenotype distributionAspartate aminotransferaseSerum samplesMixed genotypesChain reactionViral RNACity of SalvadorFurther investigationAminotransferaseVirusBrazilian samplePatientsHigh frequencyGenotypes