Soluble Vascular Cell Adhesion Molecule Levels, Endothelin-1 and Endothelial Nitric Oxide Synthase Gene Polymorphisms: Association with Clinical Symptoms in Sickle Cell Anemia.
Vilas-Boas W, Figueiredo C, Cerqueira B, Pitanga T, Zanette A, Reis M, Goncalves M. Soluble Vascular Cell Adhesion Molecule Levels, Endothelin-1 and Endothelial Nitric Oxide Synthase Gene Polymorphisms: Association with Clinical Symptoms in Sickle Cell Anemia. Blood 2012, 120: 2118. DOI: 10.1182/blood.v120.21.2118.2118.Peer-Reviewed Original ResearchAcute chest syndromeT gene polymorphismEndothelial nitric oxide synthaseSoluble adhesion moleculesAdhesion molecule-1Endothelin-1HbSS patientsENOS -786TGene polymorphismsMedical historyMolecule-1Vascular cell adhesion molecule levelsEndothelial nitric oxide synthase gene polymorphismsSoluble intercellular adhesion molecule-1Nitric oxide synthase gene polymorphismsC gene promoter polymorphismsCell adhesion molecule levelsNitric oxide synthesis pathwayVascular cell adhesion molecule-1Intercellular adhesion molecule-1Adhesion moleculesCell adhesion molecule-1Levels of sICAMAdhesion molecule levelsIncreased inflammatory state