2024
Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity score matching analysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically ventilated patientsCritically ill patients
2014
Long-Term Survival in Patients With Severe Acute Respiratory Distress Syndrome and Rescue Therapies for Refractory Hypoxemia*
Khandelwal N, Hough CL, Bansal A, Veenstra DL, Treggiari MM. Long-Term Survival in Patients With Severe Acute Respiratory Distress Syndrome and Rescue Therapies for Refractory Hypoxemia*. Critical Care Medicine 2014, 42: 1610-1618. PMID: 24732240, PMCID: PMC4061153, DOI: 10.1097/ccm.0000000000000322.Peer-Reviewed Original ResearchConceptsSevere acute respiratory distress syndromeAcute respiratory distress syndromeRespiratory distress syndromeLong-term survivalRescue therapyProportional hazards modelHospital mortalityDistress syndromeICU admissionHazard ratioHospital dischargeSevere acute respiratory distress syndrome (ARDS) patientsAcute respiratory distress syndrome survivorsConventional treatmentAcute respiratory distress syndrome patientsPaO2/FiO2 ratioBetter long-term survivalRespiratory distress syndrome patientsLevel 1 trauma centerMeeting study inclusion criteriaCox proportional hazards modelHigher hospital mortalityKaplan-Meier methodState death registryStudy inclusion criteria