2015
Randomized Pilot Trial of Intensive Management of Blood Pressure or Volume Expansion in Subarachnoid Hemorrhage (IMPROVES)
Togashi K, Joffe AM, Sekhar L, Kim L, Lam A, Yanez D, Broeckel-Elrod JA, Moore A, Deem S, Khandelwal N, Souter MJ, Treggiari MM. Randomized Pilot Trial of Intensive Management of Blood Pressure or Volume Expansion in Subarachnoid Hemorrhage (IMPROVES). Neurosurgery 2015, 76: 125-135. PMID: 25549192, DOI: 10.1227/neu.0000000000000592.Peer-Reviewed Original ResearchConceptsRankin Scale scoreCerebral ischemiaSubarachnoid hemorrhageCBP groupBlood pressureLarge trialsPilot trialScale scoreOptimal blood pressure managementSystolic blood pressure differenceModified Rankin Scale scoreBlood pressure manipulationIntravenous fluid intakeWorse neurobehavioral outcomesBlood pressure managementBlood pressure differenceDelayed Cerebral IschemiaRandomized pilot trialPulmonary complicationsAdverse eventsDischarge dispositionHemodynamic managementStudy endpointPatient populationProtocol adherence
2011
Hemodynamic Management of Subarachnoid Hemorrhage
Treggiari MM, Participants in the International Multi-disciplinary Consensus Conference on the Critical Care Management of Subarachnoid Hemorrhage. Hemodynamic Management of Subarachnoid Hemorrhage. Neurocritical Care 2011, 15: 329. PMID: 21786046, DOI: 10.1007/s12028-011-9589-5.Peer-Reviewed Original ResearchConceptsHemodynamic augmentation therapyHemodynamic augmentationUnsecured aneurysmsAugmentation therapySubarachnoid hemorrhageHigher cerebral blood flowBlood pressure augmentationBlood pressure managementCerebral blood flowElectronic literature searchEnglish language papersInotropic therapyCerebral ischemiaHemodynamic managementVolume statusInotropic agentsStandard treatmentSymptom reversalAneurysmal ruptureEligible reportsBlood flowSide effectsPatientsPressure augmentationIncremental risk
2009
Which H is the most important in triple-H therapy for cerebral vasospasm?
Treggiari MM, Deem S. Which H is the most important in triple-H therapy for cerebral vasospasm? Current Opinion In Critical Care 2009, 15: 83-86. PMID: 19276798, DOI: 10.1097/mcc.0b013e32832922d1.Peer-Reviewed Original ResearchConceptsCerebral vasospasmSubarachnoid hemorrhageCirculatory volume expansionNew randomized trialsCerebral blood flowHemodynamic managementRandomized trialsHemodynamic variablesHypervolemic hemodilutionRegistry databaseBlood flowPaucity of informationVasospasmPhysiologic dataHemorrhagePhysiological studiesLow levelsHypertensionComplicationsHemodilutionTherapyRecent literatureTrials